ID   Q0BS82_GRABC            Unreviewed;       811 AA.
AC   Q0BS82;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN   OrderedLocusNames=GbCGDNIH1_1422 {ECO:0000313|EMBL:ABI62320.1};
OS   Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Granulibacter.
OX   NCBI_TaxID=391165 {ECO:0000313|EMBL:ABI62320.1, ECO:0000313|Proteomes:UP000001963};
RN   [1] {ECO:0000313|EMBL:ABI62320.1, ECO:0000313|Proteomes:UP000001963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1260 / CGDNIH1 {ECO:0000313|Proteomes:UP000001963};
RX   PubMed=17827295; DOI=10.1128/JB.00793-07;
RA   Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E.,
RA   Kupko J.J.III., Barbian K.D., Babar A., Dorward D.W., Holland S.M.;
RT   "Genome sequence analysis of the emerging human pathogenic acetic acid
RT   bacterium Granulibacter bethesdensis.";
RL   J. Bacteriol. 189:8727-8736(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP000394; ABI62320.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0BS82; -.
DR   STRING; 391165.GbCGDNIH1_1422; -.
DR   KEGG; gbe:GbCGDNIH1_1422; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_347730_0_0_5; -.
DR   OrthoDB; 7293398at2; -.
DR   Proteomes; UP000001963; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd18773; PDC1_HK_sensor; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45627:SF30; -; 1.
DR   PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001963};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          627..763
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   811 AA;  88611 MW;  5D330BCC77C7A1EF CRC64;
     MPEPAESRRV YTAPVMRPHG ASQEIAFLQA AEQPTEVIDP TGQRQERNRR KLRRVLLPTI
     GITLVLGSMF AIGYHSYILV RTNTIKLSNE LLNATQNYIA QEVTTYLSPA QLGSRLVQDL
     LQHGALDNNG KLFNFYAGGM LRQVPQIQAF YLANSDGDFA LVQRDGNGGT EIVLVSAGPG
     GVRLRSVMRN NANGELISSD PPSPDPYDPR TSSYYQQPVR TRQPYWSPPY IFKPTGRPVI
     TTSTAYHNAD TRDHVIAVNI SLDQLSSFLD SLKIGEHGYA VIAQKNGQIV ASRDVLGQAA
     LDPVKAHIAA EPKTGQDTPL SRAFNIFHVS GYGPGSFTLK RGQDSEDYVF IAARLPAGAP
     DWVLLIVLPT KDFAAFGTRD SRSMLLYSGM TVALAMVLAG LLIRQGRRVE HVMDVLTDQN
     QRAEDERRSL QQLMSHPDIF DGNEEAPILT EHLASVSQAQ RASIWHIGRN GRTLHCEDIY
     DRRRDSHMGG FSLGMTEAGP LLEAIEGGEA FTIQDAAADP RTERLYRLHM RNSQTRSLSV
     QPIPDQDGFV GAIMLEDAGR LAESRHIVSI LSGIVGIRLR SQTEAAMMPD LSMPQTIATQ
     SAPLQPMATE SSLLSPHDQP GWDSLQNGVF PSIVAMVITF DVQPLAMSNQ ADQAAIIRLV
     GDMASDFQEI ARTHDIFSLK LAGHRLFAVS GCSSTPDPQA ALQMGDAALA IRDACITRLA
     GEEIDPNFHI GIDVGPAMGA WLGKDPAVFN IWGQALQGAE AMTQGNALPG SIQVTEAAYK
     LLRSHFLFRN RGAFYTPQTG ISRAYSMAGR Q
//