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Q0BS63

- LPXB_GRABC

UniProt

Q0BS63 - LPXB_GRABC

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, GbCGDNIH1_1441
Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciGBET391165:GHON-1478-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:GbCGDNIH1_1441
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000072224Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_1441.

Structurei

3D structure databases

ProteinModelPortaliQ0BS63.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BS63-1 [UniParc]FASTAAdd to Basket

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MTAPLIYIVA GEHSGDVLGA RLIHALRAIN PSIRFAGIGG PRMEECGFQS    50
LFPMHELAVM GLIEILPRVL KLRRRLQQTV QDIETRRPDL VLTIDSPGFC 100
LRLLRAIQPF GIKRVHYVAP QVWAWREHRV KRFPGLWERM LCLLPFEEKW 150
FAERNVPGQF VGHPVLESGA DQGDAARFRA RHSLADNARV IVLMPGSRAN 200
EAGRLLPVYG ETLRLLMQNI PTITPVIPLA SSTAHTVRGA VSSWPVQPIF 250
ITDIADKHDA FAAAEAALTK SGTSTLELAM GGVPMAVTYR VNRITAMMAR 300
RLIRVPYVAM VNLLAGREIV PELLQENCTP TKIAAVLTSL MNNAPDTNGM 350
GAADSQKQAL KAVVASLHAP NRHASDGLPS SAAAASIMEV LGQ 393
Length:393
Mass (Da):42,932
Last modified:October 17, 2006 - v1
Checksum:iD2588B438EDED191
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI62339.1.
RefSeqiWP_011632143.1. NC_008343.1.
YP_745262.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI62339; ABI62339; GbCGDNIH1_1441.
GeneIDi4274942.
KEGGigbe:GbCGDNIH1_1441.
PATRICi22079063. VBIGraBet83793_1493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI62339.1 .
RefSeqi WP_011632143.1. NC_008343.1.
YP_745262.1. NC_008343.1.

3D structure databases

ProteinModelPortali Q0BS63.
ModBasei Search...

Protein-protein interaction databases

STRINGi 391165.GbCGDNIH1_1441.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI62339 ; ABI62339 ; GbCGDNIH1_1441 .
GeneIDi 4274942.
KEGGi gbe:GbCGDNIH1_1441.
PATRICi 22079063. VBIGraBet83793_1493.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci GBET391165:GHON-1478-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiLPXB_GRABC
AccessioniPrimary (citable) accession number: Q0BS63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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