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Q0BS63

- LPXB_GRABC

UniProt

Q0BS63 - LPXB_GRABC

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciGBET391165:GHON-1478-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:GbCGDNIH1_1441
    OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
    Taxonomic identifieri391165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
    ProteomesiUP000001963: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Lipid-A-disaccharide synthasePRO_1000072224Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391165.GbCGDNIH1_1441.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BS63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0BS63-1 [UniParc]FASTAAdd to Basket

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    MTAPLIYIVA GEHSGDVLGA RLIHALRAIN PSIRFAGIGG PRMEECGFQS    50
    LFPMHELAVM GLIEILPRVL KLRRRLQQTV QDIETRRPDL VLTIDSPGFC 100
    LRLLRAIQPF GIKRVHYVAP QVWAWREHRV KRFPGLWERM LCLLPFEEKW 150
    FAERNVPGQF VGHPVLESGA DQGDAARFRA RHSLADNARV IVLMPGSRAN 200
    EAGRLLPVYG ETLRLLMQNI PTITPVIPLA SSTAHTVRGA VSSWPVQPIF 250
    ITDIADKHDA FAAAEAALTK SGTSTLELAM GGVPMAVTYR VNRITAMMAR 300
    RLIRVPYVAM VNLLAGREIV PELLQENCTP TKIAAVLTSL MNNAPDTNGM 350
    GAADSQKQAL KAVVASLHAP NRHASDGLPS SAAAASIMEV LGQ 393
    Length:393
    Mass (Da):42,932
    Last modified:October 17, 2006 - v1
    Checksum:iD2588B438EDED191
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000394 Genomic DNA. Translation: ABI62339.1.
    RefSeqiWP_011632143.1. NC_008343.1.
    YP_745262.1. NC_008343.1.

    Genome annotation databases

    EnsemblBacteriaiABI62339; ABI62339; GbCGDNIH1_1441.
    GeneIDi4274942.
    KEGGigbe:GbCGDNIH1_1441.
    PATRICi22079063. VBIGraBet83793_1493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000394 Genomic DNA. Translation: ABI62339.1 .
    RefSeqi WP_011632143.1. NC_008343.1.
    YP_745262.1. NC_008343.1.

    3D structure databases

    ProteinModelPortali Q0BS63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391165.GbCGDNIH1_1441.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI62339 ; ABI62339 ; GbCGDNIH1_1441 .
    GeneIDi 4274942.
    KEGGi gbe:GbCGDNIH1_1441.
    PATRICi 22079063. VBIGraBet83793_1493.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci GBET391165:GHON-1478-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
      Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
      J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1260 / CGDNIH1.

    Entry informationi

    Entry nameiLPXB_GRABC
    AccessioniPrimary (citable) accession number: Q0BS63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3