Q0BRP7 (Q0BRP7_GRABC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	GbCGDNIH1_1607

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI62505.1

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867 EMBL ABI62505.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	8 – 37	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	480	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	Q0BRP7 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 3378519364BB98A1	FASTA	575	63,193
	10 20 30 40 50 60 MSNLQEYDYI VIGAGSAGNV LATRLTEDAG TRVLLLEAGG PDYRFDFRTQ MPAALAYPLQ 70 80 90 100 110 120 GRRYNWAFET EPEPFMNNRR MECGRGKGLG GSSLINGMCY IRGNAMDYDG WAERDGLEEW 130 140 150 160 170 180 SYAHCLPYFR KAETRDIGPN DYHGGDGPVS VITSKLGRPG GGANPLFEAM VEAGVQAGYP 190 200 210 220 230 240 RTDDLNGYQQ EGFGPMDRTV TKQGRRASTA RGYLDQARKR KNLTILTHAL TDRILFAGKR 250 260 270 280 290 300 AIGVAFLHGG ESKIAYARQE VLLCGGAIAS PAILQRSGVG PASVLKALDI APVQIMEGVG 310 320 330 340 350 360 SNLQDHLEMY MQYECLEPVS LYPALLWWNQ PKIGAEWMFL GKGLGASNHF EAGGFIRSHD 370 380 390 400 410 420 DFAWPNIQYH FLPVAISYNG TNAVQMHGFQ AHVGSMRSPS RGRVQIVSRD PEVYPSILFN 430 440 450 460 470 480 YMSHEQDWRE FRAAIRITRE IMAQPALDQY RGRELSPGVE LTSDADLDAF VRSHAETAYH 490 500 510 520 530 540 PSCSCKMGTD DAAVVDAEGR VHGLEGLRVV DASIMPLITT GNLNAPTIMM AEKIADRIRG 550 560 570 RAPLPPSDAP YYRADGAPVR GTCARRAFGH DVNVS

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI62505.1.
RefSeq	YP_745428.1. NC_008343.1.
3D structure databases
ProteinModelPortal	Q0BRP7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BRP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4276049.
GenomeReviews	Gene locus GbCGDNIH1_1607 in contig CP000394_GR.
KEGG	gbe:GbCGDNIH1_1607.
NMPDR	fig|391165.8.peg.1571.
PATRIC	22079405. VBIGraBet83793_1663.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	RSTAPYY.
PhylomeDB	Q0BRP7.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0BRP7_GRABC

Accession

Primary (citable) accession number: Q0BRP7

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)