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Protein

Catalase-peroxidase

Gene

katG

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei121 – 1211Transition state stabilizerUniRule annotation
Active sitei125 – 1251Proton acceptorUniRule annotation
Metal bindingi286 – 2861Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciGBET391165:GHON-1717-MONOMER.

Protein family/group databases

PeroxiBasei7329. GbeCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:GbCGDNIH1_1677
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
Proteomesi
  • UP000001963 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4545UniRule annotationAdd
BLAST
Chaini46 – 760715Catalase-peroxidasePRO_0000354805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki124 ↔ 245Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-271)UniRule annotation
Cross-linki245 ↔ 271Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-124)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_1677.

Structurei

3D structure databases

ProteinModelPortaliQ0BRH7.
SMRiQ0BRH7. Positions 55-757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0BRH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGTPFRSPH LYQEGSSCMH RTIRSVAAVL TVVLSATIPM VPAWSDGEPR
60 70 80 90 100
SIQFWWPDHL DLSPLRQHAA ESDPLGANFN YIKAFQTLDL GAVKKDIAVL
110 120 130 140 150
LKTPQDWWPA DYGNYGPFFI RMAWHGAGTY RTYDGRGGAS GAQQRFEPLN
160 170 180 190 200
SWPDNANLDK ARRLLWPIKK KYGEKLSWGD LMVLTGNVAL ETMGFKTYGF
210 220 230 240 250
AGGRTDDWEP DLIYWGSGAK FMSNNRDKNG KLEKPLAATQ MGLIYVNPEG
260 270 280 290 300
PNGVPDPVAA ARDIREAFGG MAMDDEETVA LIAGGHTFGK AHGAASPSKC
310 320 330 340 350
VGPAPAAAGI EEQGLGWKNK CGTGKGPDAI TSGLEGAWSA DPVNFTSQYL
360 370 380 390 400
DNLFGFDWVL TKSPGGAVQW KPKDASADQL VPDAFDASKR HPPMMFTTDI
410 420 430 440 450
ALKTDPSYRK IALSFQKDPE KFKAAFARAW FKLVHRDMGP RSRYFGPEVP
460 470 480 490 500
KEDLLWQDPL PAITYKAVDE ADITDLKQKI LASGLTVPEL VRTAWGSAAS
510 520 530 540 550
FRGTDKRGGA NGARIRLAPE KDWPVNDPQE LKKVLDKLES IQTAFNDGNH
560 570 580 590 600
DGKKISLADL IVLGGNVGVE EAAKKAGYPV TVPFAPGRVD AVQAQTDVKS
610 620 630 640 650
FAVLEPTADG FRNYYASSNQ LSPAEMLVTR ASMLNLTVPE MTVLVGGMRV
660 670 680 690 700
LDANEGHSQL GVLTDHPGVL SNDFFVNLLD MSTKWSKAAD TAGVYEGHDR
710 720 730 740 750
KTDALRWKGS TVDLIFGSNS ELRAVAEVYA SDDAKEKFVR DFVAAWNKVM
760
TLDRFDLQRQ
Length:760
Mass (Da):83,184
Last modified:October 17, 2006 - v1
Checksum:i368607ECC3D2B891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI62575.1.

Genome annotation databases

EnsemblBacteriaiABI62575; ABI62575; GbCGDNIH1_1677.
KEGGigbe:GbCGDNIH1_1677.
PATRICi22079553. VBIGraBet83793_1735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI62575.1.

3D structure databases

ProteinModelPortaliQ0BRH7.
SMRiQ0BRH7. Positions 55-757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_1677.

Protein family/group databases

PeroxiBasei7329. GbeCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI62575; ABI62575; GbCGDNIH1_1677.
KEGGigbe:GbCGDNIH1_1677.
PATRICi22079553. VBIGraBet83793_1735.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciGBET391165:GHON-1717-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_GRABC
AccessioniPrimary (citable) accession number: Q0BRH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.