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Protein

Ribonuclease H

Gene

rnhA

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Magnesium 1UniRule annotation1
Metal bindingi16Magnesium 2UniRule annotation1
Metal bindingi54Magnesium 1UniRule annotation1
Metal bindingi76Magnesium 1UniRule annotation1
Metal bindingi140Magnesium 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotation
Ordered Locus Names:GbCGDNIH1_1877
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
Proteomesi
  • UP000001963 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003326091 – 150Ribonuclease HAdd BLAST150

Proteomic databases

PRIDEiQ0BQX7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_1877

Structurei

3D structure databases

ProteinModelPortaliQ0BQX7
SMRiQ0BQX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 148RNase HUniRule annotationAdd BLAST142

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UMW Bacteria
COG0328 LUCA
HOGENOMiHOG000040465
KOiK03469
OMAiMQEIEIF
OrthoDBiPOG091H04XT

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BQX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTMQGESNI VEIWTDGGCK PNPGPGGWAA ILLYRGTEKE LSGFDPETTN
60 70 80 90 100
NRMELTAAAA ALEALTRPCK VVLNTDSEYV RNGITRWKDG WVRRNWRNAS
110 120 130 140 150
GDPVANMDLW RRLLDAAARH EIDWRWVRGH AGNPMNERAD QLATKARMEG
Length:150
Mass (Da):16,866
Last modified:October 17, 2006 - v1
Checksum:iAAAB1504AC953A2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA Translation: ABI62775.1

Genome annotation databases

EnsemblBacteriaiABI62775; ABI62775; GbCGDNIH1_1877
KEGGigbe:GbCGDNIH1_1877

Similar proteinsi

Entry informationi

Entry nameiRNH_GRABC
AccessioniPrimary (citable) accession number: Q0BQX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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