Reviewed, UniProtKB/Swiss-Prot Q0BQS6 (PQQC_GRABC)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	GbCGDNIH1_1928

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP]

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_1000061669

Sequences

	Sequence		Length	Mass (Da)
	Q0BQS6-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 957C05947C1C7782	FASTA	255	28,760
	10 20 30 40 50 60 MTQLHNRTAG QETNRVMTPD ELEAALRAVG AERYHNLHPF HRLLHDGALT RGQVQAWALN 70 80 90 100 110 120 RYHYQASIPA KDAALLSRLP TAELRREWRR RLVDHDGTEP GTGGIARWLK LAEGVGLDAA 130 140 150 160 170 180 YVESREGLLP TTRFAVDAYV TFCREKPILE AIASSLTEMF SPTIIRERVS GMLANYDWVS 190 200 210 220 230 240 EETLAYFKPR LTQAPRDVDF ALAYVKEHAR TPEQQQAVIA ALRFKCDVLW SQLDALYYSY 250 VAPGNIPPGA FVPEV

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI62826.1.
RefSeq	YP_745749.1.
3D structure databases
SMR	Q0BQS6. Positions 14-253.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BQS6.
Genome annotation databases
GeneID	4274447.
GenomeReviews	Gene locus GbCGDNIH1_1928 in contig CP000394_GR.
KEGG	gbe:GbCGDNIH1_1928.
NMPDR	fig|391165.8.peg.1869.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5424.
HOGENOM	HBG288944.
OMA	FRDRATR.
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_GRABC

Accession

Primary (citable) accession number: Q0BQS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)