Q0BQ60 (Q0BQ60_GRABC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE HAMAP MF_00222
Ordered Locus Names:	GbCGDNIH1_2144

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI63042.1

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ABI63042.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	147 – 151	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	87	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q0BQ60 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 19C823303586BECC	FASTA	289	30,278
	10 20 30 40 50 60 MVSDGMTSSI VSAPLCSGLS GAARLAGVIG WPVQHSRSPK LHGHWLARYR IDGAYVPLAV 70 80 90 100 110 120 PPERFETAVR GLVACGFRGA NVTIPHKQAA LALCDEVEDQ ALLAGAVNTL VFENERIIGR 130 140 150 160 170 180 NTDGDGFIAN VRDHGIDPSA GPVLLFGAGG AARGIAAALS AWVPVTLCAR RDEAAAELAA 190 200 210 220 230 240 LLPNVSAVPW SRREDVLKEH ALVVNTTAAG MEGHPALEID LSRAPDGLAV ADIVYTPLET 250 260 270 280 PLLHAARLRG LPVAEGLGML LHQARPGFRS WFGVEPEVDD ALRTAVLAG

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI63042.1.
RefSeq	YP_745965.1. NC_008343.1.
3D structure databases
ProteinModelPortal	Q0BQ60.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BQ60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4276817.
GenomeReviews	Gene locus GbCGDNIH1_2144 in contig CP000394_GR.
KEGG	gbe:GbCGDNIH1_2144.
NMPDR	fig|391165.8.peg.2083.
PATRIC	22080553. VBIGraBet83793_2225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	GIANELY.
PhylomeDB	Q0BQ60.
ProtClustDB	CLSK848676.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0BQ60_GRABC

Accession

Primary (citable) accession number: Q0BQ60

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)