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Q0BPY6

- Q0BPY6_GRABC

UniProt

Q0BPY6 - Q0BPY6_GRABC

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Protein
Alanine racemase
Gene
GbCGDNIH1_2218
Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei131 – 1311Substrate By similarityUniRule annotation
Active sitei253 – 2531Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei301 – 3011Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciGBET391165:GHON-2268-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:GbCGDNIH1_2218Imported
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)Imported
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_2218.

Structurei

3D structure databases

ProteinModelPortaliQ0BPY6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BPY6-1 [UniParc]FASTAAdd to Basket

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MARLEIDLEA IAANWRFLRT THGTNRITGA VVKADGYGLG AAVIAQRLVQ    50
EGCDHIFVAH PQEALTLRPL IPSATLIVLN GLWPGWEAAY TDHGLIPALG 100
SLAEIEAWRQ EATRREQALP AFLHVDTGIN RLGLDPQERD RLAERPELLD 150
GITLRAIMTH LISAEIPDHD SNTLQRQRFA AACSRLPPAP RSIANSSGIF 200
LGPDFASDIA RPGAALYGIN PVPGRPNPMR PVLRLSARVL QIRPVEAGEI 250
VGYNGIWVAQ RPSRIAVCSV GYADGFQRAL SSRAEAAFDG ARIPLVGRVS 300
MDLTTYDVTD DPRITVGSWL ELIGPEVSPD EVAARASTNG YEVLTSLGRR 350
YERVYRPLTP 360
Length:360
Mass (Da):39,235
Last modified:October 17, 2006 - v1
Checksum:i6B55086F7C965A23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI63116.1.
RefSeqiYP_746039.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI63116; ABI63116; GbCGDNIH1_2218.
GeneIDi4276575.
KEGGigbe:GbCGDNIH1_2218.
PATRICi22080701. VBIGraBet83793_2299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI63116.1 .
RefSeqi YP_746039.1. NC_008343.1.

3D structure databases

ProteinModelPortali Q0BPY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391165.GbCGDNIH1_2218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI63116 ; ABI63116 ; GbCGDNIH1_2218 .
GeneIDi 4276575.
KEGGi gbe:GbCGDNIH1_2218.
PATRICi 22080701. VBIGraBet83793_2299.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi FIMSHLA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci GBET391165:GHON-2268-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J.III., Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiQ0BPY6_GRABC
AccessioniPrimary (citable) accession number: Q0BPY6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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