Q0BP62 (Q0BP62_FRATO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide deformylase 1 HAMAP MF_00163
Short name=PDF 1 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163

Alternative name(s):
Polypeptide deformylase 1 HAMAP MF_00163

Gene names

Name:	def EMBL ABI82122.1
Synonyms:	def1 HAMAP MF_00163
Ordered Locus Names:	FTH_0070

Organism

Francisella tularensis subsp. holarctica (strain OSU18) [Complete proteome] [HAMAP]

Taxonomic identifier

393011 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163
Catalytic activity	Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 SAAS SAAS000181
Cofactor	Binds 1 Fe2+ ion By similarity. HAMAP MF_00163
Sequence similarities	Belongs to the polypeptide deformylase family. HAMAP MF_00163 RuleBase RU003335

Ontologies

Keywords
Biological process	Protein biosynthesis SAAS SAAS000181 HAMAP MF_00163
Ligand	Iron HAMAP MF_00163 Metal-binding HAMAP MF_00163 SAAS SAAS000181
Molecular function	Hydrolase HAMAP MF_00163 SAAS SAAS000181 EMBL ABI82122.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro peptide deformylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	137	1	By similarity HAMAP MF_00163
	Metal binding	94	1	Iron By similarity HAMAP MF_00163
	Metal binding	136	1	Iron By similarity HAMAP MF_00163
	Metal binding	140	1	Iron By similarity HAMAP MF_00163

Sequences

	Sequence		Length	Mass (Da)
	Q0BP62 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 8DB640B5F4A76FF1	FASTA	172	19,579
	10 20 30 40 50 60 MSLEILKYPH PVLKEVAKEV TKDEINDDLR ATIAEMHELM LEANGVGLAA IQVGIKKRFF 70 80 90 100 110 120 IMYDNLEEQN PEIITIINPE IIEQNGKIID EEGCLSFPGV SAKVNRATVV KIKALNEFGE 130 140 150 160 170 EIEVEKDGFL ARCIQHEIDH LNGITFFDHL GSLKRKMIEK KYKKLMQENA KS

References

[1]

"Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence." Petrosino J.F., Xiang Q., Karpathy S.E., Jiang H., Yerrapragada S., Liu Y., Gioia J., Hemphill L., Gonzalez A., Raghavan T.M., Uzman A., Fox G.E., Highlander S., Reichard M., Morton R.J., Clinkenbeard K.D., Weinstock G.M. J. Bacteriol. 188:6977-6985(2006) [PubMed: 16980500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000437 Genomic DNA. Translation: ABI82122.1.
RefSeq	YP_762759.1. NC_008369.1.
3D structure databases
ProteinModelPortal	Q0BP62.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BP62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4307210.
GenomeReviews	Gene locus FTH_0070 in contig CP000437_GR.
KEGG	fth:FTH_0070.
PATRIC	17949820. VBIFraTul3936_0084.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0242.
HOGENOM	HBG665227.
OMA	EMTELMI.
ProtClustDB	CLSK935135.
Family and domain databases
HAMAP	MF_00163. Pep_deformylase. [Tree]
InterPro	IPR000181. Fmet_deformylase. IPR023635. Peptide_deformylase. [Graphical view]
Gene3D	G3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KO	K01462.
PANTHER	PTHR10458. Fmet_deformylase. 1 hit.
Pfam	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PIRSF	PIRSF004749. Pep_def. 1 hit.
PRINTS	PR01576. PDEFORMYLASE.
SUPFAM	SSF56420. Fmet_deformylase. 1 hit.
TIGRFAMs	TIGR00079. Pept_deformyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0BP62_FRATO

Accession

Primary (citable) accession number: Q0BP62

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)