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Q0BNB6

- LSPA_FRATO

UniProt

Q0BNB6 - LSPA_FRATO

Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

    Catalytic activityi

    Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei113 – 1131UniRule annotation
    Active sitei140 – 1401UniRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciFTUL393011:GHFN-438-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
    Alternative name(s):
    Prolipoprotein signal peptidaseUniRule annotation
    Signal peptidase IIUniRule annotation
    Short name:
    SPase IIUniRule annotation
    Gene namesi
    Name:lspAUniRule annotation
    Ordered Locus Names:FTH_0427
    OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
    Taxonomic identifieri393011 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000650: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Lipoprotein signal peptidasePRO_0000289380Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi393011.FTH_0427.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei67 – 8721HelicalUniRule annotationAdd
    BLAST
    Transmembranei91 – 11121HelicalUniRule annotationAdd
    BLAST
    Transmembranei136 – 15621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096992.
    KOiK03101.
    OMAiLENAGGW.
    OrthoDBiEOG6PGKBM.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BNB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLRPKLKY FILAILIIAA DLYTKYLANT YLEFAQSLKI TSFFNLTLLY    50
    NHGAAFSLLS NDQTSWQMIM FSTISLIAAI VLIYLIIKQP ITEKINLFSF 100
    ALILGGALGN FYDRAFQGYV IDFLDFHIGN YHWPSFNIAD SAITCGVVIL 150
    IAASLFTKKK S 161
    Length:161
    Mass (Da):18,181
    Last modified:October 17, 2006 - v1
    Checksum:iF3E5194B95D253FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82418.1.
    RefSeqiYP_763055.1. NC_008369.1.

    Genome annotation databases

    EnsemblBacteriaiABI82418; ABI82418; FTH_0427.
    GeneIDi4306475.
    KEGGifth:FTH_0427.
    PATRICi17950654. VBIFraTul3936_0489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82418.1 .
    RefSeqi YP_763055.1. NC_008369.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393011.FTH_0427.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI82418 ; ABI82418 ; FTH_0427 .
    GeneIDi 4306475.
    KEGGi fth:FTH_0427.
    PATRICi 17950654. VBIFraTul3936_0489.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096992.
    KOi K03101.
    OMAi LENAGGW.
    OrthoDBi EOG6PGKBM.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci FTUL393011:GHFN-438-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU18.

    Entry informationi

    Entry nameiLSPA_FRATO
    AccessioniPrimary (citable) accession number: Q0BNB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3