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Q0BMY1

- Q0BMY1_FRATO

UniProt

Q0BMY1 - Q0BMY1_FRATO

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Protein
Submitted name: Isocitrate dehydrogenase (NADP(+))
Gene
FTH_0588
Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521Substrate By similarityUniRule annotation
Sitei262 – 2621Critical for catalysis By similarityUniRule annotation
Metal bindingi357 – 3571Magnesium or manganese By similarityUniRule annotation
Sitei427 – 4271Critical for catalysis By similarityUniRule annotation
Binding sitei554 – 5541Substrate By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation
Metal bindingi559 – 5591Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-608-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:FTH_0588Imported
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)Imported
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi393011.FTH_0588.

Structurei

3D structure databases

ProteinModelPortaliQ0BMY1.
SMRiQ0BMY1. Positions 12-747.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1468Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BMY1-1 [UniParc]FASTAAdd to Basket

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MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS    50
LSARILANFN DYLTAEQKCS DDLAILRELA KTPDANIIKL PNISASIPQL 100
TAAIKELQSK GYKIPDYPYE PKDDKEQEIK ARYAKVLGSA VNPVLREGNS 150
DRRVADAVKK YAEKHPHSMG EWTKDSKSHV ASMSADDFYA NEKSYIVPKA 200
TKVKIVHIDT KDTQTVLKDN LALEEKEIID ATKISIKALR EFYKNEIAKA 250
KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP 300
RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SDKGITNLNV 350
PSDVIIDASM PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC 400
KENGAFDVAT MGDVSNVGLM AKKAEEYGSH DKTFEIQADG KVEVIDAEGN 450
VIFEHQVEKG DIWRACQTKD IAVKDWVKLV VNRAKITQNP AIFWLDSKRA 500
HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK EGKNTISVTG 550
NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL 600
IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN 650
DKSPRRKVGE LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA 700
NKDKIVKELN DAQGKKVDVG GYYHMDKVKL DAVMRPSKTF NTILAQI 747
Length:747
Mass (Da):83,584
Last modified:October 17, 2006 - v1
Checksum:i0D2DB2BCA07C3F97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI82553.1.
RefSeqiWP_003014963.1. NC_008369.1.
YP_763190.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI82553; ABI82553; FTH_0588.
GeneIDi4308091.
KEGGifth:FTH_0588.
PATRICi17951015. VBIFraTul3936_0659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI82553.1 .
RefSeqi WP_003014963.1. NC_008369.1.
YP_763190.1. NC_008369.1.

3D structure databases

ProteinModelPortali Q0BMY1.
SMRi Q0BMY1. Positions 12-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393011.FTH_0588.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI82553 ; ABI82553 ; FTH_0588 .
GeneIDi 4308091.
KEGGi fth:FTH_0588.
PATRICi 17951015. VBIFraTul3936_0659.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci FTUL393011:GHFN-608-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18Imported.

Entry informationi

Entry nameiQ0BMY1_FRATO
AccessioniPrimary (citable) accession number: Q0BMY1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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