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Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene

FTH_0588

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-608-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:FTH_0588Imported
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)Imported
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi393011.FTH_0588.

Structurei

3D structure databases

ProteinModelPortaliQ0BMY1.
SMRiQ0BMY1. Positions 12-747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BMY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS
60 70 80 90 100
LSARILANFN DYLTAEQKCS DDLAILRELA KTPDANIIKL PNISASIPQL
110 120 130 140 150
TAAIKELQSK GYKIPDYPYE PKDDKEQEIK ARYAKVLGSA VNPVLREGNS
160 170 180 190 200
DRRVADAVKK YAEKHPHSMG EWTKDSKSHV ASMSADDFYA NEKSYIVPKA
210 220 230 240 250
TKVKIVHIDT KDTQTVLKDN LALEEKEIID ATKISIKALR EFYKNEIAKA
260 270 280 290 300
KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP
310 320 330 340 350
RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SDKGITNLNV
360 370 380 390 400
PSDVIIDASM PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC
410 420 430 440 450
KENGAFDVAT MGDVSNVGLM AKKAEEYGSH DKTFEIQADG KVEVIDAEGN
460 470 480 490 500
VIFEHQVEKG DIWRACQTKD IAVKDWVKLV VNRAKITQNP AIFWLDSKRA
510 520 530 540 550
HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK EGKNTISVTG
560 570 580 590 600
NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL
610 620 630 640 650
IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN
660 670 680 690 700
DKSPRRKVGE LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA
710 720 730 740
NKDKIVKELN DAQGKKVDVG GYYHMDKVKL DAVMRPSKTF NTILAQI
Length:747
Mass (Da):83,584
Last modified:October 17, 2006 - v1
Checksum:i0D2DB2BCA07C3F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI82553.1.
RefSeqiYP_763190.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI82553; ABI82553; FTH_0588.
GeneIDi4308091.
KEGGifth:FTH_0588.
PATRICi17951015. VBIFraTul3936_0659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI82553.1.
RefSeqiYP_763190.1. NC_008369.1.

3D structure databases

ProteinModelPortaliQ0BMY1.
SMRiQ0BMY1. Positions 12-747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393011.FTH_0588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI82553; ABI82553; FTH_0588.
GeneIDi4308091.
KEGGifth:FTH_0588.
PATRICi17951015. VBIFraTul3936_0659.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-608-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18Imported.

Entry informationi

Entry nameiQ0BMY1_FRATO
AccessioniPrimary (citable) accession number: Q0BMY1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: February 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.