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Q0BMY1

- Q0BMY1_FRATO

UniProt

Q0BMY1 - Q0BMY1_FRATO

Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene

FTH_0588

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521Substrate
    Sitei262 – 2621Critical for catalysisUniRule annotation
    Metal bindingi357 – 3571Magnesium or manganeseUniRule annotation
    Sitei427 – 4271Critical for catalysisUniRule annotation
    Binding sitei554 – 5541SubstrateUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation
    Metal bindingi559 – 5591Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFTUL393011:GHFN-608-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:FTH_0588Imported
    OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)Imported
    Taxonomic identifieri393011 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000650: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi393011.FTH_0588.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BMY1.
    SMRiQ0BMY1. Positions 12-747.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1468Substrate binding

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0BMY1-1 [UniParc]FASTAAdd to Basket

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    MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS    50
    LSARILANFN DYLTAEQKCS DDLAILRELA KTPDANIIKL PNISASIPQL 100
    TAAIKELQSK GYKIPDYPYE PKDDKEQEIK ARYAKVLGSA VNPVLREGNS 150
    DRRVADAVKK YAEKHPHSMG EWTKDSKSHV ASMSADDFYA NEKSYIVPKA 200
    TKVKIVHIDT KDTQTVLKDN LALEEKEIID ATKISIKALR EFYKNEIAKA 250
    KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP 300
    RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SDKGITNLNV 350
    PSDVIIDASM PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC 400
    KENGAFDVAT MGDVSNVGLM AKKAEEYGSH DKTFEIQADG KVEVIDAEGN 450
    VIFEHQVEKG DIWRACQTKD IAVKDWVKLV VNRAKITQNP AIFWLDSKRA 500
    HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK EGKNTISVTG 550
    NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL 600
    IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN 650
    DKSPRRKVGE LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA 700
    NKDKIVKELN DAQGKKVDVG GYYHMDKVKL DAVMRPSKTF NTILAQI 747
    Length:747
    Mass (Da):83,584
    Last modified:October 17, 2006 - v1
    Checksum:i0D2DB2BCA07C3F97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82553.1.
    RefSeqiWP_003014963.1. NC_008369.1.
    YP_763190.1. NC_008369.1.

    Genome annotation databases

    EnsemblBacteriaiABI82553; ABI82553; FTH_0588.
    GeneIDi4308091.
    KEGGifth:FTH_0588.
    PATRICi17951015. VBIFraTul3936_0659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82553.1 .
    RefSeqi WP_003014963.1. NC_008369.1.
    YP_763190.1. NC_008369.1.

    3D structure databases

    ProteinModelPortali Q0BMY1.
    SMRi Q0BMY1. Positions 12-747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393011.FTH_0588.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI82553 ; ABI82553 ; FTH_0588 .
    GeneIDi 4308091.
    KEGGi fth:FTH_0588.
    PATRICi 17951015. VBIFraTul3936_0659.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci FTUL393011:GHFN-608-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU18Imported.

    Entry informationi

    Entry nameiQ0BMY1_FRATO
    AccessioniPrimary (citable) accession number: Q0BMY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3