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Q0BMU7

- NADK_FRATO

UniProt

Q0BMU7 - NADK_FRATO

Protein

NAD kinase

Gene

nadK

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Binding sitei78 – 781NADUniRule annotation
    Binding sitei178 – 1781NADUniRule annotation
    Binding sitei180 – 1801NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 742NADUniRule annotation
    Nucleotide bindingi151 – 1522NADUniRule annotation
    Nucleotide bindingi191 – 1966NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFTUL393011:GHFN-650-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:FTH_0629
    OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
    Taxonomic identifieri393011 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000650: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296NAD kinasePRO_1000005410Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi393011.FTH_0629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BMU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiGAEFCLN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0BMU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFKYHKVAI VGKHYKKEVS QMVETLYAYL QQQGLEIIVE NDTAADTSLV    50
    NVAIASLKEI ALRCDVAIVV GGDGNFLKAS RLLALYSNIP VIGINKGKLG 100
    FLTTLAADDN ALKNDLYAIL KGDSSVTKMS MLKCRVDNNL RAPLEASIAL 150
    NEIAITASRG LMFGLKVFID GRYAFDQRGD GLIVSTPTGS TAHAMSAGGP 200
    ILNPNQNSVV LVPICSHSLN SRPLVISDES VIDIYITDYN DPEPVLSIDG 250
    RHDTILKAHQ KVTIQKARKK VTVLHTKDYN YYDTLREKLG WSKVLF 296
    Length:296
    Mass (Da):32,411
    Last modified:October 17, 2006 - v1
    Checksum:i00B501C1E7346605
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82587.1.
    RefSeqiYP_763224.1. NC_008369.1.

    Genome annotation databases

    EnsemblBacteriaiABI82587; ABI82587; FTH_0629.
    GeneIDi4308133.
    KEGGifth:FTH_0629.
    PATRICi17951104. VBIFraTul3936_0702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI82587.1 .
    RefSeqi YP_763224.1. NC_008369.1.

    3D structure databases

    ProteinModelPortali Q0BMU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393011.FTH_0629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI82587 ; ABI82587 ; FTH_0629 .
    GeneIDi 4308133.
    KEGGi fth:FTH_0629.
    PATRICi 17951104. VBIFraTul3936_0702.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi GAEFCLN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci FTUL393011:GHFN-650-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU18.

    Entry informationi

    Entry nameiNADK_FRATO
    AccessioniPrimary (citable) accession number: Q0BMU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3