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Q0BMU5

- TRMB_FRATO

UniProt

Q0BMU5 - TRMB_FRATO

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionineUniRule annotation
Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
Binding sitei114 – 1141S-adenosyl-L-methionineUniRule annotation
Active sitei137 – 1371By similarity
Binding sitei137 – 1371S-adenosyl-L-methionineUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-652-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:FTH_0631
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229tRNA (guanine-N(7)-)-methyltransferasePRO_0000288150Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393011.FTH_0631.

Structurei

3D structure databases

ProteinModelPortaliQ0BMU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 1486Interaction with RNAUniRule annotation
Regioni208 – 2114Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiTSATNDY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BMU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCDKSKENLR QIKSYVQRAG RVTKKQQQAL DNYAAKYLIE YAKDRKLDFT
60 70 80 90 100
EIFANTNDVV LEIGFGMGGS LVEMALANPA KNYLGIEVHK AGVGNILYEI
110 120 130 140 150
EHQNIANLLV MSHDAVEILE NMIADQSLAS IQVYFPDPWH KKKHNKRRLV
160 170 180 190 200
NQTNIDLFAK KLKVGGVFHY ASDWLPYAEE VLELLENDSK YRNLYSGFAP
210 220
RPEWRPLTKF EKRGQNLDHP ISDILFEKI
Length:229
Mass (Da):26,385
Last modified:October 17, 2006 - v1
Checksum:i9B52D52645F6474F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI82589.1.
RefSeqiYP_763226.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI82589; ABI82589; FTH_0631.
GeneIDi4308135.
KEGGifth:FTH_0631.
PATRICi17951108. VBIFraTul3936_0704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI82589.1 .
RefSeqi YP_763226.1. NC_008369.1.

3D structure databases

ProteinModelPortali Q0BMU5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393011.FTH_0631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI82589 ; ABI82589 ; FTH_0631 .
GeneIDi 4308135.
KEGGi fth:FTH_0631.
PATRICi 17951108. VBIFraTul3936_0704.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi TSATNDY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci FTUL393011:GHFN-652-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18.

Entry informationi

Entry nameiTRMB_FRATO
AccessioniPrimary (citable) accession number: Q0BMU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 17, 2006
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3