ID   BIOD_FRATO              Reviewed;         219 AA.
AC   Q0BLD2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=FTH_1248;
OS   Francisella tularensis subsp. holarctica (strain OSU18).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=393011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980500; DOI=10.1128/JB.00506-06;
RA   Petrosino J.F., Xiang Q., Karpathy S.E., Jiang H., Yerrapragada S.,
RA   Liu Y., Gioia J., Hemphill L., Gonzalez A., Raghavan T.M., Uzman A.,
RA   Fox G.E., Highlander S., Reichard M., Morton R.J., Clinkenbeard K.D.,
RA   Weinstock G.M.;
RT   "Chromosome rearrangement and diversification of Francisella
RT   tularensis revealed by the type B (OSU18) genome sequence.";
RL   J. Bacteriol. 188:6977-6985(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000437; ABI83102.1; -; Genomic_DNA.
DR   RefSeq; YP_763739.1; -.
DR   GeneID; 4307534; -.
DR   GenomeReviews; CP000437_GR; FTH_1248.
DR   KEGG; fth:FTH_1248; -.
DR   HOGENOM; Q0BLD2; -.
DR   OMA; Q0BLD2; CLIEGAG.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    219       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302506.
FT   NP_BIND       8     16       ATP (By similarity).
SQ   SEQUENCE   219 AA;  24502 MW;  090B0BF3DAD24657 CRC64;
     MKKFFIIGTN TEVGKTYIST KLIEVCEHQN IKSLCLKPVA SGQSQFSELC EDVESILNAY
     KHKFTAAEIN LISFNQAVAP HIIAAKTKVD ISIENLKQFI EDKYNQDLDI LFIEGAGGLL
     TPYSDHTTQL DLIKALQIPV LLVSAIKVGC INHTLLTINE LNRHNIKLAG WIANCNDSNI
     KYIDEQINTI EELSGYKCSA KISRNADYLD FIDLSKILI
//