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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:FTH_1257
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000200671 – 313Methionyl-tRNA formyltransferaseAdd BLAST313

Structurei

3D structure databases

ProteinModelPortaliQ0BLC5.
SMRiQ0BLC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiView protein in PROSITE
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BLC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLNIIFAG TPDISAQVLK DLYKSQHNIQ AVLTQPDRAK GRGKKVQFSP
60 70 80 90 100
VKEVALANHT PVFQPLSFKK NPEVLEQIKQ LKPDVIVVIA YGIIVPQEFL
110 120 130 140 150
DIPRYGCLNI HVSLLPKWRG AAPIQRAIQA GDTKTGVCIM QMDAGLDTGD
160 170 180 190 200
ILNTLEIEIQ ETDTSQTLHD KFAKLSIKPL LETLEKIEII KPEPQQGEPT
210 220 230 240 250
YAHKITKQEG LIDFTKSAWR ISCHIRAFTP WPGAYFILDD EAIKVGEFEI
260 270 280 290 300
LYQNTDNRKA GTIIDIYRSG FDIATSDKII RFRQLQFPNK KMLNIVDILN
310
GKDLDKYIGY KLG
Length:313
Mass (Da):35,353
Last modified:October 17, 2006 - v1
Checksum:iF59D5D71EE1348A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI83109.1.
RefSeqiWP_003016443.1. NC_017463.1.

Genome annotation databases

EnsemblBacteriaiABI83109; ABI83109; FTH_1257.
KEGGifth:FTH_1257.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFMT_FRATO
AccessioniPrimary (citable) accession number: Q0BLC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families