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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:FTH_1257
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000200671 – 313Methionyl-tRNA formyltransferaseAdd BLAST313

Structurei

3D structure databases

ProteinModelPortaliQ0BLC5
SMRiQ0BLC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BLC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLNIIFAG TPDISAQVLK DLYKSQHNIQ AVLTQPDRAK GRGKKVQFSP
60 70 80 90 100
VKEVALANHT PVFQPLSFKK NPEVLEQIKQ LKPDVIVVIA YGIIVPQEFL
110 120 130 140 150
DIPRYGCLNI HVSLLPKWRG AAPIQRAIQA GDTKTGVCIM QMDAGLDTGD
160 170 180 190 200
ILNTLEIEIQ ETDTSQTLHD KFAKLSIKPL LETLEKIEII KPEPQQGEPT
210 220 230 240 250
YAHKITKQEG LIDFTKSAWR ISCHIRAFTP WPGAYFILDD EAIKVGEFEI
260 270 280 290 300
LYQNTDNRKA GTIIDIYRSG FDIATSDKII RFRQLQFPNK KMLNIVDILN
310
GKDLDKYIGY KLG
Length:313
Mass (Da):35,353
Last modified:October 17, 2006 - v1
Checksum:iF59D5D71EE1348A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA Translation: ABI83109.1
RefSeqiWP_003016443.1, NC_017463.1

Genome annotation databases

EnsemblBacteriaiABI83109; ABI83109; FTH_1257
KEGGifth:FTH_1257

Similar proteinsi

Entry informationi

Entry nameiFMT_FRATO
AccessioniPrimary (citable) accession number: Q0BLC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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