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Q0BL54

- KGUA_FRATO

UniProt

Q0BL54 - KGUA_FRATO

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Protein
Guanylate kinase
Gene
gmk, FTH_1353
Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-1384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:FTH_1353
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Guanylate kinaseUniRule annotation
PRO_0000266326Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393011.FTH_1353.

Structurei

3D structure databases

ProteinModelPortaliQ0BL54.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 185183Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiFAVATSH.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BL54-1 [UniParc]FASTAAdd to Basket

« Hide

MNNYIFIISA PSGAGKSSLL KAFLATDIGK DNYAVAISHT TREPRVGEIN    50
SREYYFVTVA EFEQLLSQDG FIEYAKVFKN YYGTSKAELD RLLALGKNII 100
LEINWQGAQQ TRAIYGDRAK SIFILPPSLD ELRKRLEKRN TDSKETIDYR 150
MEQVQSEISH ADEYDYLLVN DDFSQSLEQL CKYFEQNIQS 190
Length:190
Mass (Da):21,865
Last modified:October 17, 2006 - v1
Checksum:i9C40BD21114B6D8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI83180.1.
RefSeqiYP_763817.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI83180; ABI83180; FTH_1353.
GeneIDi4307756.
KEGGifth:FTH_1353.
PATRICi17952845. VBIFraTul3936_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI83180.1 .
RefSeqi YP_763817.1. NC_008369.1.

3D structure databases

ProteinModelPortali Q0BL54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393011.FTH_1353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI83180 ; ABI83180 ; FTH_1353 .
GeneIDi 4307756.
KEGGi fth:FTH_1353.
PATRICi 17952845. VBIFraTul3936_1554.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
KOi K00942.
OMAi FAVATSH.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci FTUL393011:GHFN-1384-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18.

Entry informationi

Entry nameiKGUA_FRATO
AccessioniPrimary (citable) accession number: Q0BL54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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