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Q0BKV5

- TDH_FRATO

UniProt

Q0BKV5 - TDH_FRATO

Protein

L-threonine 3-dehydrogenase

Gene

tdh

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Zinc 1; catalyticUniRule annotation
    Metal bindingi64 – 641Zinc 1; catalyticUniRule annotation
    Metal bindingi94 – 941Zinc 2UniRule annotation
    Metal bindingi97 – 971Zinc 2UniRule annotation
    Metal bindingi100 – 1001Zinc 2UniRule annotation
    Metal bindingi108 – 1081Zinc 2UniRule annotation
    Metal bindingi149 – 1491Zinc 1; catalyticUniRule annotation

    GO - Molecular functioni

    1. L-threonine 3-dehydrogenase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-threonine catabolic process to glycine Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciFTUL393011:GHFN-1509-MONOMER.
    UniPathwayiUPA00046; UER00505.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-threonine 3-dehydrogenaseUniRule annotation (EC:1.1.1.103UniRule annotation)
    Gene namesi
    Name:tdhUniRule annotation
    Ordered Locus Names:FTH_1473
    OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
    Taxonomic identifieri393011 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000650: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351L-threonine 3-dehydrogenasePRO_1000051640Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi393011.FTH_1473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BKV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1063.
    HOGENOMiHOG000294686.
    KOiK00060.
    OMAiYKMASLL.
    OrthoDBiEOG60PH85.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    HAMAPiMF_00627. Thr_dehydrog.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR004627. L-Threonine_3-DHase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    TIGRFAMsiTIGR00692. tdh. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BKV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALAKLKKQ PGIWMINDAP IPEYGYNDVL IKIKKTAICG TDLHIYNWDK    50
    WSQNTIPVPM ITGHEFAGEV VAKGDGVTSV DIGDRVSGEG HLVCGQCRNC 100
    RAGKRHLCRK TIGIGVNVQG AFAEYLVMPA VNVFKIPDSI SDDIASTFDP 150
    MGNAIHTALS FNLTGEDVLI TGAGPIGLMA VKIARFCGAR RIVITDINEY 200
    RLQMARDFGA TVALNVAPFK NQDELVKQMR KVMSDIGMTE GFDVGLEMSG 250
    INSAISMMLD VMNHGGKLSL LGISAGDISV DWGAILFKGL TLKGIYGREM 300
    FETWYLMTSM LQAGMDMNPI ITHRLHIDEF QKGFEIMKSG QCGKVILDWS 350
    S 351
    Length:351
    Mass (Da):38,400
    Last modified:October 17, 2006 - v1
    Checksum:i1E07E9CCC5A58A79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI83279.1.
    RefSeqiYP_763916.1. NC_008369.1.

    Genome annotation databases

    EnsemblBacteriaiABI83279; ABI83279; FTH_1473.
    GeneIDi4307881.
    KEGGifth:FTH_1473.
    PATRICi17953132. VBIFraTul3936_1691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000437 Genomic DNA. Translation: ABI83279.1 .
    RefSeqi YP_763916.1. NC_008369.1.

    3D structure databases

    ProteinModelPortali Q0BKV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393011.FTH_1473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI83279 ; ABI83279 ; FTH_1473 .
    GeneIDi 4307881.
    KEGGi fth:FTH_1473.
    PATRICi 17953132. VBIFraTul3936_1691.

    Phylogenomic databases

    eggNOGi COG1063.
    HOGENOMi HOG000294686.
    KOi K00060.
    OMAi YKMASLL.
    OrthoDBi EOG60PH85.

    Enzyme and pathway databases

    UniPathwayi UPA00046 ; UER00505 .
    BioCyci FTUL393011:GHFN-1509-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    HAMAPi MF_00627. Thr_dehydrog.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR004627. L-Threonine_3-DHase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    TIGRFAMsi TIGR00692. tdh. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU18.

    Entry informationi

    Entry nameiTDH_FRATO
    AccessioniPrimary (citable) accession number: Q0BKV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3