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Q0BKV5

- TDH_FRATO

UniProt

Q0BKV5 - TDH_FRATO

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Protein

L-threonine 3-dehydrogenase

Gene
tdh, FTH_1473
Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Zinc 1; catalytic By similarity
Metal bindingi64 – 641Zinc 1; catalytic By similarity
Metal bindingi94 – 941Zinc 2 By similarity
Metal bindingi97 – 971Zinc 2 By similarity
Metal bindingi100 – 1001Zinc 2 By similarity
Metal bindingi108 – 1081Zinc 2 By similarity
Metal bindingi149 – 1491Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. L-threonine 3-dehydrogenase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-threonine catabolic process to glycine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-1509-MONOMER.
UniPathwayiUPA00046; UER00505.

Names & Taxonomyi

Protein namesi
Recommended name:
L-threonine 3-dehydrogenase (EC:1.1.1.103)
Gene namesi
Name:tdh
Ordered Locus Names:FTH_1473
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351L-threonine 3-dehydrogenaseUniRule annotationPRO_1000051640Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi393011.FTH_1473.

Structurei

3D structure databases

ProteinModelPortaliQ0BKV5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1063.
HOGENOMiHOG000294686.
KOiK00060.
OMAiYKMASLL.
OrthoDBiEOG60PH85.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
HAMAPiMF_00627. Thr_dehydrog.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR004627. L-Threonine_3-DHase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
TIGRFAMsiTIGR00692. tdh. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BKV5-1 [UniParc]FASTAAdd to Basket

« Hide

MKALAKLKKQ PGIWMINDAP IPEYGYNDVL IKIKKTAICG TDLHIYNWDK    50
WSQNTIPVPM ITGHEFAGEV VAKGDGVTSV DIGDRVSGEG HLVCGQCRNC 100
RAGKRHLCRK TIGIGVNVQG AFAEYLVMPA VNVFKIPDSI SDDIASTFDP 150
MGNAIHTALS FNLTGEDVLI TGAGPIGLMA VKIARFCGAR RIVITDINEY 200
RLQMARDFGA TVALNVAPFK NQDELVKQMR KVMSDIGMTE GFDVGLEMSG 250
INSAISMMLD VMNHGGKLSL LGISAGDISV DWGAILFKGL TLKGIYGREM 300
FETWYLMTSM LQAGMDMNPI ITHRLHIDEF QKGFEIMKSG QCGKVILDWS 350
S 351
Length:351
Mass (Da):38,400
Last modified:October 17, 2006 - v1
Checksum:i1E07E9CCC5A58A79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI83279.1.
RefSeqiYP_763916.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI83279; ABI83279; FTH_1473.
GeneIDi4307881.
KEGGifth:FTH_1473.
PATRICi17953132. VBIFraTul3936_1691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000437 Genomic DNA. Translation: ABI83279.1 .
RefSeqi YP_763916.1. NC_008369.1.

3D structure databases

ProteinModelPortali Q0BKV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393011.FTH_1473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI83279 ; ABI83279 ; FTH_1473 .
GeneIDi 4307881.
KEGGi fth:FTH_1473.
PATRICi 17953132. VBIFraTul3936_1691.

Phylogenomic databases

eggNOGi COG1063.
HOGENOMi HOG000294686.
KOi K00060.
OMAi YKMASLL.
OrthoDBi EOG60PH85.

Enzyme and pathway databases

UniPathwayi UPA00046 ; UER00505 .
BioCyci FTUL393011:GHFN-1509-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
HAMAPi MF_00627. Thr_dehydrog.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR004627. L-Threonine_3-DHase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
TIGRFAMsi TIGR00692. tdh. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18.

Entry informationi

Entry nameiTDH_FRATO
AccessioniPrimary (citable) accession number: Q0BKV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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