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Q0BKU1

- PNP_FRATO

UniProt

Q0BKU1 - PNP_FRATO

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891MagnesiumUniRule annotation
Metal bindingi495 – 4951MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-1524-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:FTH_1487
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000650: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Polyribonucleotide nucleotidyltransferasePRO_0000329651Add
BLAST

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

Protein-protein interaction databases

STRINGi393011.FTH_1487.

Structurei

3D structure databases

ProteinModelPortaliQ0BKU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61560KHUniRule annotationAdd
BLAST
Domaini625 – 69369S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BKU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFREVFEL GNKEIILETG GMARQADGSV TVSCGNNVVL VTTVVKKSVA
60 70 80 90 100
DGTDFFPLSV HYLEKTYAAG KIPGGFLRRE GRPSEEQILI SRLIDRSIRP
110 120 130 140 150
SFPDGFFNEI QIVATVLSYD GAFSPDILAL IGASASLAIS GAPYDDVVAG
160 170 180 190 200
VRVGYTNGKY ILNPNKQDLR DSDLDLVVSG TYDAILMVES EANSLPESVM
210 220 230 240 250
LGGILYAHKH LKTIINSINR LAKVASKPRI EYSIYQINKF LKSQIKSQFF
260 270 280 290 300
GEIKNTYTIA LKQERNLKLN AIRKNVLEYI FSSDVDGNEY TEKEILEAFH
310 320 330 340 350
DIEKDLVRSN ILEGKPRIDG RCTETIRPIN VKIGVLPGVH GSALFTRGET
360 370 380 390 400
QALVVTTLGS DRDAQLVESL DGIEKCRYML HYNFPPYSVG ECGMVGMAPK
410 420 430 440 450
RREIGHANLA KRATQAVFPN EEAYPYVVRV VSEILESNGS SSMATVCGSS
460 470 480 490 500
LSMMDAGVPI AEPVAGIAMG LIKDGAKYAV LSDILGDEDH LGDMDFKVAG
510 520 530 540 550
TRYGVTALQM DIKIKGISRE ILEQALEQAR VGRLHILGIM NEVIKEHKEA
560 570 580 590 600
VSDVAPQIHV MNINPAKIKD VVGRGGATVK GIVEKTGAQI DTSDSGEVKV
610 620 630 640 650
FAKDKKSMDM AVAMIEEIVA EVEEGQVYKG KIVKLLDSGV FVNLLGSQDG
660 670 680 690
YLPFSEIEQA GMKTNSLVEG QGLEVLVQNI DRGGRVKLSL VAR
Length:693
Mass (Da):75,528
Last modified:October 17, 2006 - v1
Checksum:i67940576098AC8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI83293.1.
RefSeqiWP_011648757.1. NC_008369.1.
YP_763930.1. NC_008369.1.

Genome annotation databases

EnsemblBacteriaiABI83293; ABI83293; FTH_1487.
GeneIDi4307896.
KEGGifth:FTH_1487.
PATRICi17953162. VBIFraTul3936_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI83293.1 .
RefSeqi WP_011648757.1. NC_008369.1.
YP_763930.1. NC_008369.1.

3D structure databases

ProteinModelPortali Q0BKU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393011.FTH_1487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI83293 ; ABI83293 ; FTH_1487 .
GeneIDi 4307896.
KEGGi fth:FTH_1487.
PATRICi 17953162. VBIFraTul3936_1705.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci FTUL393011:GHFN-1524-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU18.

Entry informationi

Entry nameiPNP_FRATO
AccessioniPrimary (citable) accession number: Q0BKU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3