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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1107ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL393011:GHFN-1598-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:FTH_1561
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416UDP-N-acetylmuramoylalanine--D-glutamate ligasePRO_0000301425Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0BKM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049427.
KOiK01925.
OMAiFQLERVP.

Family and domain databases

Gene3Di3.40.1190.10. 2 hits.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BKM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFYFNDNK ITKLLMVGYG STGKSVCDFL ANFIDITVDI SQNDDEFVNY
60 70 80 90 100
DLNSYDLITV SPGIPLNKSP YRALTKFKDK IVSDIDIFYQ YIKDTKAKTI
110 120 130 140 150
AVTGSNGKST VVTMTDFVLK DLGYKSILVG NIGTPALNKI GEKFDYCVVE
160 170 180 190 200
VSSFQINLFN CVRFDLGCII NVSPDHLDRY QNFEQYKQSK LNLAKFSNDF
210 220 230 240 250
FVYDVHNGIK YAGEYQIIRG AIYRNSTKLL DIVETKLFGE HNLENIIVVL
260 270 280 290 300
NILDRLGLDI NQAIDSIKKF KGLEHRCKIV KKVNGTTYIN DSKGTNVGAT
310 320 330 340 350
IAALNSITNS KNIILLLGGV AKGGDFSLMI KSLDKYVKYV YIYGADKEYI
360 370 380 390 400
ESYIKGYCKY QLCNNMKQAF ELASQKANSN EIVLLSPACA SFDEFSGYAQ
410
RGEVFQNLVA QLEQKS
Length:416
Mass (Da):46,779
Last modified:October 17, 2006 - v1
Checksum:iC99E35540681C1FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI83356.1.
RefSeqiWP_003017010.1. NC_017463.1.

Genome annotation databases

EnsemblBacteriaiABI83356; ABI83356; FTH_1561.
KEGGifth:FTH_1561.
PATRICi17953330. VBIFraTul3936_1788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA. Translation: ABI83356.1.
RefSeqiWP_003017010.1. NC_017463.1.

3D structure databases

ProteinModelPortaliQ0BKM8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI83356; ABI83356; FTH_1561.
KEGGifth:FTH_1561.
PATRICi17953330. VBIFraTul3936_1788.

Phylogenomic databases

HOGENOMiHOG000049427.
KOiK01925.
OMAiFQLERVP.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciFTUL393011:GHFN-1598-MONOMER.

Family and domain databases

Gene3Di3.40.1190.10. 2 hits.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURD_FRATO
AccessioniPrimary (citable) accession number: Q0BKM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.