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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Bamb_0460
OrganismiBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Taxonomic identifieri339670 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000000662 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei222 – 242HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei286 – 306HelicalUniRule annotationAdd BLAST21
Transmembranei311 – 331HelicalUniRule annotationAdd BLAST21
Transmembranei366 – 386HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029461 – 389Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST389

Interactioni

Protein-protein interaction databases

STRINGi339670.Bamb_0460.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BIK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLALAQWLQ GDASFLRLFT YLTFRAVMAT ITALGIGLVC GPWVIRKLTQ
60 70 80 90 100
MKVGQAVRKD GPQSHLVKSG TPTMGGVLIL IGIAVATLLW GDLTNRFIWI
110 120 130 140 150
VMLVTFGFGV IGWVDDYRKV VYKDPRGMSS REKYFWQSVI GLFAAVYLAF
160 170 180 190 200
SVSEANNVRV FDLFMAWVRS GLSMGLPARA DLMLPFLKSI SYPLGVWGFI
210 220 230 240 250
VLTYFVIVGA SNAVNLTDGL DGLVIMPVVL VGGSLGVFAY VMGSSVYSKY
260 270 280 290 300
LLFPHIPGAG ELLIFCSAMG GAGLAFLWYN THPAQVFMGD VGALALGGAL
310 320 330 340 350
GTVAVIVRQE IVLFIMGGIF VAETLSVMLQ VSWFKYTKKR YGEGRRLLKM
360 370 380
APLHHHFELS GWKETQVVVR FWIITLMLCL FGLSTLKLR
Length:389
Mass (Da):42,808
Last modified:October 17, 2006 - v1
Checksum:iAC4F02036861D3EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000440 Genomic DNA. Translation: ABI86019.1.
RefSeqiWP_006752439.1. NZ_CP009798.1.

Genome annotation databases

EnsemblBacteriaiABI86019; ABI86019; Bamb_0460.
KEGGibam:Bamb_0460.
PATRICifig|339670.21.peg.1146.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BURCM
AccessioniPrimary (citable) accession number: Q0BIK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families