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Q0BIK0 (MURC_BURCM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:Bamb_0464
OrganismBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP]
Taxonomic identifier339670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_1000004319

Regions

Nucleotide binding112 – 1187ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q0BIK0 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 9F5985295DCC78E6

FASTA46548,979
        10         20         30         40         50         60 
MKHIVKQIHF VGIGGAGMSG IAEVLVNLGY EVSGSDLSRN AVTDRLEALG ARIAIGHDAA 

        70         80         90        100        110        120 
NIAGANAVVV STAVRSDNPE VLAARHQGVP IVQRAVMLAE LMRLKQGIAI AGTHGKTTTT 

       130        140        150        160        170        180 
SLVASVLAAG GLDPTFVIGG RLISAGANAR LGTGDFIVAE ADESDASFLN LYPVIEVITN 

       190        200        210        220        230        240 
IDADHMDTYG HDFARLKQAF IEFTQRLPFY GSAVVCVDDP NVRQIIPFIS KPVVRYGLSP 

       250        260        270        280        290        300 
DAQVRAEDID ARDGRMHFTV IREGRAPLAV VLNLPGLHNV QNALAAIAIA TDLGVSDDAI 

       310        320        330        340        350        360 
QQALAEFNGV GRRFQRYGEV PSADGGQYTL IDDYGHHPVE MAATVAAARG AFPGRRLVLA 

       370        380        390        400        410        420 
FQPHRYTRTR DCFDDFVNVL STVDALVLTE VYAAGEAAIT TANGDALSRA LRAVGRVDPV 

       430        440        450        460 
FVASVDDVPD ALAGVARNGD VVITMGAGSI GGVPAKIVQH IQQKA

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cepacia AMMD."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-244 / AMMD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000440 Genomic DNA. Translation: ABI86023.1.
RefSeqYP_772357.1. NC_008390.1.

3D structure databases

ProteinModelPortalQ0BIK0.
SMRQ0BIK0. Positions 1-460.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0BIK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4311153.
GenomeReviewsGene locus Bamb_0464 in contig CP000440_GR.
KEGGbam:Bamb_0464.
NMPDRfig|339670.3.peg.6101.
PATRIC19016422. VBIBurAmb61564_0522.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHBG476594.
OMAYQPHRYS.
PhylomeDBQ0BIK0.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycBAMB339670:BAMB_0464-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BURCM
AccessionPrimary (citable) accession number: Q0BIK0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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