ID   HGD_BURCM               Reviewed;         444 AA.
AC   Q0BHW3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   05-MAY-2009, entry version 18.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=Bamb_0701;
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia
OS   cepacia (strain AMMD)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Parke J., Coenye T.,
RA   Konstantinidis K., Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000440; ABI86260.1; -; Genomic_DNA.
DR   RefSeq; YP_772594.1; -.
DR   GeneID; 4309714; -.
DR   GenomeReviews; CP000440_GR; Bamb_0701.
DR   KEGG; bam:Bamb_0701; -.
DR   NMPDR; fig|339670.3.peg.3109; -.
DR   OMA; Q0BHW3; HRNCMSE.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    444       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019523.
FT   METAL       341    341       Iron (By similarity).
FT   METAL       347    347       Iron (By similarity).
FT   METAL       377    377       Iron (By similarity).
SQ   SEQUENCE   444 AA;  49032 MW;  FA49EAFE21E728E2 CRC64;
     MTLDLSKPAT AGYLSGFANE FATEALPGAL PHGRNSPQRA PYGLYAEQLS GTAFTAPRGH
     NRRSWLYRIR PAAVHRPFEP FTGPQRLVSE FGDSADVPPT PPNQLRWDPL PMPVEPTDFV
     EGLVTMAGNG SAAAMNGCAI HLYAANRSMQ DRFFYSADGE LLIVPQQGRL FIATEFGRLD
     VEPFEIAVIP RGVRFSVALP DGDARGYICE NFGALLRLPD LGPIGSNGLA NPRDFLTPQA
     AYEDREGAFE LVAKLNGRLW RADIGHSPFD VVAWHGNYAP YKYDLRLFNT IGSISFDHPD
     PSIFLVLQSQ SDTPGVDAID FVIFPPRWLA AEDTFRPPWF HRNVASEFMG LVHGAYDAKA
     EGFVPGGASL HNCMSGHGPD ADTFEKASAS DTTKPHKVDA TMAFMFETRT LIRPTRYALD
     TAQLQPDYFE CWQGIRKHFN PEQP
//