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Q0BHW3

- HGD_BURCM

UniProt

Q0BHW3 - HGD_BURCM

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei298 – 2981Proton acceptorUniRule annotation
    Metal bindingi341 – 3411IronUniRule annotation
    Metal bindingi347 – 3471IronUniRule annotation
    Binding sitei356 – 3561homogentisateUniRule annotation
    Metal bindingi377 – 3771IronUniRule annotation
    Binding sitei377 – 3771homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBAMB339670:GH48-723-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:Bamb_0701
    OrganismiBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
    Taxonomic identifieri339670 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000662: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Homogentisate 1,2-dioxygenasePRO_1000019523Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi339670.Bamb_0701.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0BHW3-1 [UniParc]FASTAAdd to Basket

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    MTLDLSKPAT AGYLSGFANE FATEALPGAL PHGRNSPQRA PYGLYAEQLS    50
    GTAFTAPRGH NRRSWLYRIR PAAVHRPFEP FTGPQRLVSE FGDSADVPPT 100
    PPNQLRWDPL PMPVEPTDFV EGLVTMAGNG SAAAMNGCAI HLYAANRSMQ 150
    DRFFYSADGE LLIVPQQGRL FIATEFGRLD VEPFEIAVIP RGVRFSVALP 200
    DGDARGYICE NFGALLRLPD LGPIGSNGLA NPRDFLTPQA AYEDREGAFE 250
    LVAKLNGRLW RADIGHSPFD VVAWHGNYAP YKYDLRLFNT IGSISFDHPD 300
    PSIFLVLQSQ SDTPGVDAID FVIFPPRWLA AEDTFRPPWF HRNVASEFMG 350
    LVHGAYDAKA EGFVPGGASL HNCMSGHGPD ADTFEKASAS DTTKPHKVDA 400
    TMAFMFETRT LIRPTRYALD TAQLQPDYFE CWQGIRKHFN PEQP 444
    Length:444
    Mass (Da):49,032
    Last modified:October 17, 2006 - v1
    Checksum:iFA49EAFE21E728E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000440 Genomic DNA. Translation: ABI86260.1.
    RefSeqiYP_772594.1. NC_008390.1.

    Genome annotation databases

    EnsemblBacteriaiABI86260; ABI86260; Bamb_0701.
    GeneIDi4309714.
    KEGGibam:Bamb_0701.
    PATRICi19016918. VBIBurAmb61564_0768.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000440 Genomic DNA. Translation: ABI86260.1 .
    RefSeqi YP_772594.1. NC_008390.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 339670.Bamb_0701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI86260 ; ABI86260 ; Bamb_0701 .
    GeneIDi 4309714.
    KEGGi bam:Bamb_0701.
    PATRICi 19016918. VBIBurAmb61564_0768.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci BAMB339670:GH48-723-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-244 / AMMD.

    Entry informationi

    Entry nameiHGD_BURCM
    AccessioniPrimary (citable) accession number: Q0BHW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3