Q0BHS4 (PYRB_BURCM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Bamb_0740

Organism

Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP]

Taxonomic identifier

339670 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia ambifaria

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000321078

Sequences

	Sequence		Length	Mass (Da)
	Q0BHS4 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 9DBB0D6229CE1A98	FASTA	343	37,277
	10 20 30 40 50 60 MTTDTTGRTG NPAAAASPER FRYGFLKGNP QLTKNGELKH LLSIEGLPRS IVNHILDTAE 70 80 90 100 110 120 QFVSVTDREV KKVPLLRGKS VFNLFFENST RTRTTFEIAA TRLSADVLNL NINASSTSKG 130 140 150 160 170 180 ESLLDTINNL SAMHADLFVV RHASSGAPYL IAEHCAPHVH VINAGDGRHA HPTQGLLDMY 190 200 210 220 230 240 TIRHYKRDFT KLRVAIVGDI LHSRVARSDI HALTTLGVPE VRAIGPRTLL PGGLEQMGVK 250 260 270 280 290 300 VFNNLDEGLK GVDVIIMLRL QNERMSGALL PSAQEYFKTW GLTPERLALA APDAIVMHPG 310 320 330 340 PMNRGVEIDS QVADGPQSVI LNQVTFGIAV RMAVMGIVAG NSD

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cepacia AMMD." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-244 / AMMD.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000440 Genomic DNA. Translation: ABI86299.1.
RefSeq	YP_772633.1. NC_008390.1.
3D structure databases
ProteinModelPortal	Q0BHS4.
ModBase	Search...
Protein-protein interaction databases
STRING	339670.Bamb_0740.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABI86299; ABI86299; Bamb_0740.
GeneID	4309299.
KEGG	bam:Bamb_0740.
PATRIC	19017000. VBIBurAmb61564_0809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	MTLNAMR.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	BAMB339670:GH48-4199-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BURCM

Accession

Primary (citable) accession number: Q0BHS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program