ID   UPPP1_BURCM             Reviewed;         276 AA.
AC   Q0BHM0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Undecaprenyl-diphosphatase 1;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 1;
DE   AltName: Full=Bacitracin resistance protein 1;
GN   Name=uppP1; OrderedLocusNames=Bamb_0794;
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia
OS   cepacia (strain AMMD)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Parke J., Coenye T.,
RA   Konstantinidis K., Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000440; ABI86353.1; -; Genomic_DNA.
DR   RefSeq; YP_772687.1; -.
DR   GeneID; 4308977; -.
DR   GenomeReviews; CP000440_GR; Bamb_0794.
DR   KEGG; bam:Bamb_0794; -.
DR   NMPDR; fig|339670.3.peg.3020; -.
DR   OMA; Q0BHM0; RWLLRYI.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; -; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
DR   TIGRFAMs; TIGR00753; undec_PP_bacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    276       Undecaprenyl-diphosphatase 1.
FT                                /FTId=PRO_0000290693.
FT   TRANSMEM      4     24       Potential.
FT   TRANSMEM     45     62       Potential.
FT   TRANSMEM     83    103       Potential.
FT   TRANSMEM    108    128       Potential.
FT   TRANSMEM    187    207       Potential.
FT   TRANSMEM    217    237       Potential.
FT   TRANSMEM    252    272       Potential.
SQ   SEQUENCE   276 AA;  30303 MW;  FAE8690EC2AD0CD9 CRC64;
     MDWILICKAL ILGVVEGLTE FLPVSSTGHL IVAGSFLNFN DAHAKTFDVV IQFGAILAVC
     WEYRQRIVSI VTGLPSRPDA QRFTLNVVIA TIPAIALGLL FEKKIKAVLF SPVPVAFALV
     VGGAIILWAE ARQRERREPP RVQSIDALTP LDALKVGLAQ CFALVPGMSR SGSTIIGGML
     FGLDRRVATE FSFFLAIPII FGATLYETVK DWQAFTVDSL GLFALGLVAA FVSAFVCVRW
     LLRFVATHDF TVFAWYRIAF GLFVLLVGYS GWLNWA
//