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Q0BHL9

- TRMB_BURCM

UniProt

Q0BHL9 - TRMB_BURCM

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
    Binding sitei111 – 1111S-adenosyl-L-methionineUniRule annotation
    Binding sitei138 – 1381S-adenosyl-L-methionineUniRule annotation
    Active sitei161 – 1611By similarity
    Binding sitei161 – 1611S-adenosyl-L-methionineUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBAMB339670:GH48-817-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Bamb_0795
    OrganismiBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
    Taxonomic identifieri339670 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000662: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255tRNA (guanine-N(7)-)-methyltransferasePRO_0000288129Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi339670.Bamb_0795.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BHL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 2354Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BHL9-1 [UniParc]FASTAAdd to Basket

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    MMHDDPNEAG LPPDDAALPD EAADGADEVN PLHHRRIRSF VTRAGRVSTG    50
    QRRALDEFGP RFVVPYAAEI PDWDAVFGRS APRILEIGFG MGASTAEIAA 100
    HRPGDDFLGV EVHEPGVGAL LKLIGEQDLP NIRIIQHDAV EVLEHMLAPE 150
    SLDGVHIFFP DPWHKARHHK RRLIQPPLVA HLASRLKPGA YLHCATDWQN 200
    YAEQMLEVLG AEPSLENTAA DYAPRPDYRP ITKFERRGLR LGHGVWDLVF 250
    RKRAG 255
    Length:255
    Mass (Da):28,399
    Last modified:October 17, 2006 - v1
    Checksum:iC98B681217D2EFE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000440 Genomic DNA. Translation: ABI86354.1.
    RefSeqiYP_772688.1. NC_008390.1.

    Genome annotation databases

    EnsemblBacteriaiABI86354; ABI86354; Bamb_0795.
    GeneIDi4308978.
    KEGGibam:Bamb_0795.
    PATRICi19017112. VBIBurAmb61564_0865.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000440 Genomic DNA. Translation: ABI86354.1 .
    RefSeqi YP_772688.1. NC_008390.1.

    3D structure databases

    ProteinModelPortali Q0BHL9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 339670.Bamb_0795.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI86354 ; ABI86354 ; Bamb_0795 .
    GeneIDi 4308978.
    KEGGi bam:Bamb_0795.
    PATRICi 19017112. VBIBurAmb61564_0865.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BAMB339670:GH48-817-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-244 / AMMD.

    Entry informationi

    Entry nameiTRMB_BURCM
    AccessioniPrimary (citable) accession number: Q0BHL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3