ID   DXR_BURCM               Reviewed;         398 AA.
AC   Q0BE21;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
DE            Short=DXP reductoisomerase;
DE            EC=1.1.1.267;
DE   AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
DE   AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
GN   Name=dxr; OrderedLocusNames=Bamb_2046;
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia
OS   cepacia (strain AMMD)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Parke J., Coenye T.,
RA   Konstantinidis K., Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADP-dependent rearrangement and reduction
CC       of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol
CC       4-phosphate (MEP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2-C-methyl-D-erythritol 4-phosphate + NADP(+)
CC       = 1-deoxy-D-xylulose 5-phosphate + NADPH.
CC   -!- COFACTOR: Divalent cation (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via
CC       DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate:
CC       step 1/6.
CC   -!- SIMILARITY: Belongs to the DXR family.
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DR   EMBL; CP000440; ABI87602.1; -; Genomic_DNA.
DR   RefSeq; YP_773936.1; -.
DR   GeneID; 4311619; -.
DR   GenomeReviews; CP000440_GR; Bamb_2046.
DR   KEGG; bam:Bamb_2046; -.
DR   NMPDR; fig|339670.3.peg.6032; -.
DR   OMA; Q0BE21; IHSMVEY.
DR   GO; GO:0030604; F:1-deoxy-D-xylulose-5-phosphate reductoisome...; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00183; -; 1.
DR   InterPro; IPR003821; DXP_reductoisomerase.
DR   InterPro; IPR013644; DXP_reductoisomerase_C.
DR   InterPro; IPR013512; DXP_reductoisomerase_N.
DR   Pfam; PF08436; DXP_redisom_C; 1.
DR   Pfam; PF02670; DXP_reductoisom; 1.
DR   PIRSF; PIRSF006205; Dxp_reductismrs; 1.
DR   TIGRFAMs; TIGR00243; Dxr; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; Metal-binding; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    398       1-deoxy-D-xylulose 5-phosphate
FT                                reductoisomerase.
FT                                /FTId=PRO_1000020225.
FT   NP_BIND       8     37       NADP (By similarity).
FT   METAL       151    151       Divalent metal cation (By similarity).
FT   METAL       153    153       Divalent metal cation (By similarity).
FT   METAL       224    224       Divalent metal cation (By similarity).
FT   BINDING     126    126       Substrate (By similarity).
FT   BINDING     153    153       Substrate (By similarity).
FT   BINDING     179    179       Substrate (By similarity).
FT   BINDING     202    202       Substrate (By similarity).
FT   BINDING     224    224       Substrate (By similarity).
SQ   SEQUENCE   398 AA;  42199 MW;  6948AC58295C840E CRC64;
     MQKRLTLLGS TGSIGDSTLD VVARHPERFS VYALTAHRNG DKLVEQCLRF APEVAVVGDA
     NTAAHVEAKL RAAGSKTIVL YGPQALVDVS KSDGCDTVVA AIVGAAGLAP SLAAARAGKR
     ILLANKESLV MSGAIFMDAV RDHGAILLPV DSEHNAIFQC MPRDENEHGG ISKIILTASG
     GPFRTREPAT LADVTPDEAC KHPNWVMGRK ISVDSATMMN KGLEVIEAHW IFGLAGDRID
     VLIHPQSVIH SLVSYRDGSV LAQLGNPDMR TPIAHALAFP ERVDAGVDQL DLAQIVQLSF
     EKPDYTRFPC LALALKALEE GGIASAALNA ANEIAVEAFL ERRIGFMAIA ATVDAVLNAL
     PNRSPNGLDD VLAADAEARR LAAEIIAKAP APRVERTV
//