Reviewed,
UniProtKB/Swiss-Prot Q0BD83 (HEM6_BURCM)
Last modified
January 19, 2010.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Coproporphyrinogen-III oxidase, aerobic Short name=Coproporphyrinogenase Short name=Coprogen oxidase EC=1.3.3.3 | ||||
| Gene names |
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| Organism | Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 339670 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex |
Protein attributes
| Sequence length | 306 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 |
| Catalytic activity | Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00333 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00333. |
| Sequence similarities | Belongs to the aerobic coproporphyrinogen-III oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP protein homodimerization activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 306 | 306 | Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333 | PRO_1000019457 | |||||
Regions | |||||||||
| Region | 55 – 64 | 10 | Important for dimerization By similarity | ||||||
| Region | 115 – 117 | 3 | Substrate binding By similarity | ||||||
| Region | 247 – 282 | 36 | Important for dimerization By similarity | ||||||
| Region | 265 – 270 | 6 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 113 | 1 | Proton donor By similarity | ||||||
| Binding site | 99 | 1 | Substrate By similarity | ||||||
| Site | 182 | 1 | Important for dimerization By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. Richardson P.Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000440 Genomic DNA. Translation: ABI87890.1. |
| RefSeq | YP_774224.1. |
3D structure databases | |
| SMR | Q0BD83. Positions 5-306. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0BD83. |
Genome annotation databases | |
| GeneID | 4309131. |
| GenomeReviews | Gene locus Bamb_2334 in contig CP000440_GR. |
| KEGG | bam:Bamb_2334. |
| NMPDR | fig|339670.3.peg.5630. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0408. |
| HOGENOM | HBG631180. |
| OMA | HMNTRFV. |
Family and domain databases | |
| HAMAP | MF_00333. Coprogen_oxidas. [Tree] |
| InterPro | IPR001260. Coprogen_oxidas. IPR018375. Coproporphyrinogen-3_ox_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit. |
| PANTHER | PTHR10755. Coprogen_oxidas. 1 hit. |
| Pfam | PF01218. Coprogen_oxidas. 1 hit. [Graphical view] |
| PIRSF | PIRSF000166. Coproporphyri_ox. 1 hit. |
| PRINTS | PR00073. COPRGNOXDASE. |
| PROSITE | PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM6_BURCM | ||||||||
| Accession | Primary (citable) accession number: Q0BD83 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


