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Protein

Argininosuccinate lyase

Gene

argH

Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Bamb_2476Imported
OrganismiBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))Imported
Taxonomic identifieri339670 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000000662 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi339670.Bamb_2476

Structurei

3D structure databases

ProteinModelPortaliQ0BCU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 329Lyase_1InterPro annotationAdd BLAST294
Domaini392 – 464ASL_C2InterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.102 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BCU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELQDSLGG ARRPTPLRRI AMTSQLHKKG EAWSARFSEP MSELVKRYTS
60 70 80 90 100
SVFFDKRLAL VDIAGSLAHA SMLAAQKIIS TDDLAAIERG MTQIKGEIER
110 120 130 140 150
GEFEWQLDLE DVHLNIEARL TALIGDAGKR LHTGRSRNDQ VATDIRLWLR
160 170 180 190 200
GEIDRIGGLL NDLRGALIDL AEKNADTIMP GFTHLQVAQP VTFGHHLLAY
210 220 230 240 250
VEMFTRDAER MRDCRTRVNR LPLGAAALAG TSYPIDRHAV AKTLGFDGIC
260 270 280 290 300
ANSLDAVSDR DFAIEFAAAS ALVMTHVSRF SEELVLWMSP RVGFIDIADR
310 320 330 340 350
FCTGSSIMPQ KKNPDVPELA RGKTGRVNGH LMALLTLMKG QPLAYNKDNQ
360 370 380 390 400
EDKEPLFDTV DTVADTLRIF AEMVAGITVK PDAMRAAALQ GFSTATDLAD
410 420 430 440 450
YLVKRGLPFR DAHEAVAHAV RICDDRGIDL ADLTLDEMKQ ELPNVAHLIG
460 470 480 490
DDVFGYLTLE GSVASRNHAG GTAPDQVRAA VKAARAALGT
Length:490
Mass (Da):53,633
Last modified:October 17, 2006 - v1
Checksum:iE828E9CEA34C85D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000440 Genomic DNA Translation: ABI88032.1

Genome annotation databases

EnsemblBacteriaiABI88032; ABI88032; Bamb_2476
KEGGibam:Bamb_2476

Similar proteinsi

Entry informationi

Entry nameiQ0BCU1_BURCM
AccessioniPrimary (citable) accession number: Q0BCU1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported