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Protein

3-deoxy-manno-octulosonate cytidylyltransferase 1

Gene

kdsB1

Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase 2 (kdsB2), 3-deoxy-manno-octulosonate cytidylyltransferase 1 (kdsB1)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase 1UniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase 1UniRule annotation
Short name:
CKS 1UniRule annotation
Short name:
CMP-KDO synthase 1UniRule annotation
Gene namesi
Name:kdsB1UniRule annotation
Ordered Locus Names:Bamb_2595
OrganismiBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD))
Taxonomic identifieri339670 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000000662 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003700191 – 2633-deoxy-manno-octulosonate cytidylyltransferase 1Add BLAST263

Interactioni

Protein-protein interaction databases

STRINGi339670.Bamb_2595

Structurei

3D structure databases

ProteinModelPortaliQ0BCH2
SMRiQ0BCH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OMAiNSGTERC
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BCH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHPQPFIAV IPARLASTRL PNKPLADLGG KPMVVRVAER AREAGAQQVL
60 70 80 90 100
IASDAQSVLD AARDHGFEAV LTRADHPSGT DRLAEVAATF GWSDDTVVVN
110 120 130 140 150
VQGDEPLIDP VLVRDVASHL AAHPDCAIAT AAHPIHDAAD VFNPNVVKVA
160 170 180 190 200
LDARNVAMYF SRAPIPWSRD AYLPHWPDVS AMPAPAFPVH RHIGLYAYRA
210 220 230 240 250
RFLRTYPSLA QAPVEQAEQL EQLRAMWHGE RIAVLITEHA PEAGIDTPAD
260
LARVQALFRP GSK
Length:263
Mass (Da):28,553
Last modified:October 17, 2006 - v1
Checksum:i5FA1FC4AF1EBA660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000440 Genomic DNA Translation: ABI88151.1
RefSeqiWP_011657743.1, NZ_CP009798.1

Genome annotation databases

EnsemblBacteriaiABI88151; ABI88151; Bamb_2595
KEGGibam:Bamb_2595
PATRICifig|339670.21.peg.2307

Similar proteinsi

Entry informationi

Entry nameiKDSB1_BURCM
AccessioniPrimary (citable) accession number: Q0BCH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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