ID   BETA_BURCM              Reviewed;         566 AA.
AC   Q0B711;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=Bamb_4512;
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia
OS   cepacia (strain AMMD)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Parke J., Coenye T.,
RA   Konstantinidis K., Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; CP000441; ABI90062.1; -; Genomic_DNA.
DR   RefSeq; YP_776396.1; -.
DR   GeneID; 4313404; -.
DR   GenomeReviews; CP000441_GR; Bamb_4512.
DR   KEGG; bam:Bamb_4512; -.
DR   NMPDR; fig|339670.3.peg.4425; -.
DR   OMA; Q0B711; PNLQYHF.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    566       Choline dehydrogenase.
FT                                /FTId=PRO_1000046560.
FT   NP_BIND       7     36       FAD (Probable).
FT   ACT_SITE    474    474       By similarity.
SQ   SEQUENCE   566 AA;  62858 MW;  813DB80CFE100604 CRC64;
     MTTREYDYII CGAGSAGNVL ATRLTEDPNV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG
     RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW STHKGLENWT
     YLDCLPYFKK AETRDVGPND YHGGNGPVSV TTSKPGANPL FEAMVDAGVQ AGYPRTDDLN
     GYQQEGFGPM DRTVTPKGRR ASTARGYLDQ AKGRPNLEIV THALADRILF DGKRASGVTY
     LRGSERASAH ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPIVLDL PGVGQNLQDH
     LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN
     IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL RSRDPNAHPS ILFNYMAEAL
     DWREFRDAIR ATREIMRQPA LDRYRGRELN PGADCKSDKE LDTFVRARAE TAFHPSCSCK
     MGYDDMAVVD EEGRVHGLEG LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRQPLAR
     VDVPYFVANG AMARNVAKAV RQPETV
//