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Q0B711 (BETA_BURCM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:Bamb_4512
OrganismBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP]
Taxonomic identifier339670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Choline dehydrogenase HAMAP MF_00750
PRO_1000046560

Regions

Nucleotide binding7 – 3630FAD Potential

Sites

Active site4741 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0B711 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 813DB80CFE100604

FASTA56662,858
        10         20         30         40         50         60 
MTTREYDYII CGAGSAGNVL ATRLTEDPNV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW STHKGLENWT 

       130        140        150        160        170        180 
YLDCLPYFKK AETRDVGPND YHGGNGPVSV TTSKPGANPL FEAMVDAGVQ AGYPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTPKGRR ASTARGYLDQ AKGRPNLEIV THALADRILF DGKRASGVTY 

       250        260        270        280        290        300 
LRGSERASAH ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPIVLDL PGVGQNLQDH 

       310        320        330        340        350        360 
LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN 

       370        380        390        400        410        420 
IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL RSRDPNAHPS ILFNYMAEAL 

       430        440        450        460        470        480 
DWREFRDAIR ATREIMRQPA LDRYRGRELN PGADCKSDKE LDTFVRARAE TAFHPSCSCK 

       490        500        510        520        530        540 
MGYDDMAVVD EEGRVHGLEG LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRQPLAR 

       550        560 
VDVPYFVANG AMARNVAKAV RQPETV

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia cepacia AMMD."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-244 / AMMD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000441 Genomic DNA. Translation: ABI90062.1.
RefSeqYP_776396.1. NC_008391.1.

3D structure databases

ProteinModelPortalQ0B711.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0B711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4313404.
GenomeReviewsGene locus Bamb_4512 in contig CP000441_GR.
KEGGbam:Bamb_4512.
NMPDRfig|339670.3.peg.4425.
PATRIC19024945. VBIBurAmb61564_4728.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHBG734713.
OMARSTAPYY.
PhylomeDBQ0B711.
ProtClustDBPRK02106.

Enzyme and pathway databases

BioCycBAMB339670:BAMB_4512-MONOMER.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_BURCM
AccessionPrimary (citable) accession number: Q0B711
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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