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Q0B255 (Q0B255_BURCM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH2 HAMAP MF_01815
Ordered Locus Names:Bamb_6224
OrganismBurkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP]
Taxonomic identifier339670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region258 – 2625ACP-binding By similarity HAMAP MF_01815

Sites

Active site1211 By similarity HAMAP MF_01815
Active site2571 By similarity HAMAP MF_01815
Active site2871 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q0B255 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 8CF1DA2935D53AE3

FASTA33034,995
        10         20         30         40         50         60 
MAEITGAGSW TSRVVGCGSA LPERRVTNHD IARMVDTTDE WITQRTGIKE RRIAADGEHT 

        70         80         90        100        110        120 
SDLAIGAATA ALKQAGISGA DVDLIVLATC TPDRTMPATA VRVQEAIGMQ GGVAFDVQAV 

       130        140        150        160        170        180 
CSGFVFALSV ADNMIRLGQA RTAIVIGAET MSRIVDWQDR NTCVLFGDGA GAVVLRGERS 

       190        200        210        220        230        240 
DGDKPRGVLS THLHSDGRHH DKIHTDGGVS STQSAGKMHL EGREVFLHAV VNLAEASQEA 

       250        260        270        280        290        300 
LAAHGLTRDD LDWVVPHQAN QRIVQTLGMK LNLPMEKVVL TVGKHGNTSA ASIPLALSEA 

       310        320        330 
VSDGRIKEND LVLMPAMGSG FTWGAALIRW

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References

[1]"Complete sequence of chromosome 3 of Burkholderia cepacia AMMD."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000442 Genomic DNA. Translation: ABI91768.1.
RefSeqYP_778102.1. NC_008392.1.

3D structure databases

ProteinModelPortalQ0B255.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0B255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4315128.
GenomeReviewsGene locus Bamb_6224 in contig CP000442_GR.
KEGGbam:Bamb_6224.
NMPDRfig|339670.3.peg.468.
PATRIC19028524. VBIBurAmb61564_6506.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAFNAKEEA.
PhylomeDBQ0B255.
ProtClustDBCLSK777878.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0B255_BURCM
AccessionPrimary (citable) accession number: Q0B255
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info