Reviewed, UniProtKB/Swiss-Prot Q0B1U7 (XYLA_BURCM)

Names and origin

Protein names

Recommended name:
    Xylose isomerase
    EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Bamb_6332

Organism

Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) [Complete proteome] [HAMAP]

Taxonomic identifier

339670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Xylose isomerase HAMAP MF_00455		PRO_1000026435
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Metal binding	231	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 2 By similarity
	Metal binding	270	1	Magnesium 2 By similarity
	Metal binding	295	1	Magnesium 1 By similarity
	Metal binding	306	1	Magnesium 2 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	338	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0B1U7-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: ACC9EAFF1BDB28F9	FASTA	440	49,531
	10 20 30 40 50 60 MSYFEHIPAI RYEGPQSDNP LAYHHYDAEK RVLGKTMAEH LRIAVCYWHT FVWPGHDIFG 70 80 90 100 110 120 QGAFQRPWQQ PGDALERARL KADAAFEFFT KLGTPFYTFH DTDVAPEGDS LREYAANFAR 130 140 150 160 170 180 MVDYLGERQQ ASGVRLLWGT ANLFSHPRFA AGAATNPNPD VFAWAATQVC HALDATHRLG 190 200 210 220 230 240 GENYVLWGGR EGYETLLNTD LKRERDQFAR FLSMVVEHKH RIGFKGALLI EPKPQEPTKH 250 260 270 280 290 300 QYDYDVATVH GFLVQYGLQN EIRVNIEANH ATLAGHSFHH EIANAFALGV FGSVDANRGD 310 320 330 340 350 360 PQNGWDTDQF PNSVEELTLA FYEILRHGGF TTGGMNFDAK VRRQSVDPED LFYGHVGAID 370 380 390 400 410 420 VLALALERAA VLVENDRLDA LRRQRYAQWD DAFGQKILSG GYTLQSLADD ALARGVDPRH 430 440 ASGAQERLEN IVNQAIYGLR

References

[1]

"Complete sequence of chromosome 3 of Burkholderia cepacia AMMD." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K., Ramette A., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000442 Genomic DNA. Translation: ABI91876.1.
RefSeq	YP_778210.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4315236.
GenomeReviews	Gene locus Bamb_6332 in contig CP000442_GR.
KEGG	bam:Bamb_6332.
NMPDR	fig|339670.3.peg.569.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q0B1U7. QFLIEPK.
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase-typ_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BURCM

Accession

Primary (citable) accession number: Q0B1U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)