Q0AZJ6 (AROE_SYNWW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Swol_0524

Organism

Syntrophomonas wolfei subsp. wolfei (strain Goettingen) [Complete proteome] [HAMAP]

Taxonomic identifier

335541 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophomonas

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325178
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0AZJ6 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 6EEA0A84060C867A	FASTA	290	31,793
	10 20 30 40 50 60 MPLDIKTELM GLIGYPLQHS LSPLMHNLTL KKMGLNCIYL ALEIEEGKLP EIPSAIRTLN 70 80 90 100 110 120 FRGLNVTIPY KEKIIPFLDE LSPEAAAFGA VNVIKNKNGH LHGYNTDGRG FVEALREEGI 130 140 150 160 170 180 DPGERALFIG AGGAARSVAF ALAGLGVSRL DFLDLDFSRA RQLAEFITSR SSSLASAFLM 190 200 210 220 230 240 NTLEFQRLSR TASIIINCSP VGMFPDTGKS PVSKEDLRGS RAVLCDLIYN PLQSRFLSLG 250 260 270 280 290 QELGLETMNG LGMFVQQGAL TLEILLGQKP PLDYMKEVVQ NQLEKRVDPD

References

[1]

"Complete sequence of Syntrophomonas wolfei subsp. wolfei str. Goettingen." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Sims D., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Goettingen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000448 Genomic DNA. Translation: ABI67858.1.
RefSeq	YP_753229.1. NC_008346.1.
3D structure databases
ProteinModelPortal	Q0AZJ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AZJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4281253.
GenomeReviews	Gene locus Swol_0524 in contig CP000448_GR.
KEGG	swo:Swol_0524.
PATRIC	23855779. VBISynWol51738_0557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
PhylomeDB	Q0AZJ6.
Enzyme and pathway databases
BioCyc	SWOL335541:SWOL_0524-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_SYNWW

Accession

Primary (citable) accession number: Q0AZJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program