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Q0AZF5 (FOLD1_SYNWW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD 1

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD1
Ordered Locus Names:Swol_0566
OrganismSyntrophomonas wolfei subsp. wolfei (strain Goettingen) [Complete proteome] [HAMAP]
Taxonomic identifier335541 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophomonas

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576

Subunit structure

Homodimer By similarity. HAMAP MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Bifunctional protein FolD 1 HAMAP MF_01576
PRO_0000268539

Sequences

Sequence LengthMass (Da)Tools
Q0AZF5 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: DADC92739574C92B

FASTA27729,604
        10         20         30         40         50         60 
MEIISGSQIA QEIRQKLKEK NEREGISPCL AMILVGGQKE DLHYVGLKEK AATATGGKSR 

        70         80         90        100        110        120 
LLHLPEDTSQ QELMAKIAEL NQDEQVDGIL LQLPLPAALE EQTDEILAAI RPDKDVDGFS 

       130        140        150        160        170        180 
LVNRGRMSGD RPGFISCAAL ACLEVIERFF PSLAGKKAVL VGDSFDLIIP LATIMIKRAC 

       190        200        210        220        230        240 
QLSVLPSYEP GLASGADILV VEKGRAGIVQ AEGLAPGVLI IDAGFYWGAG GVCGNVDRAA 

       250        260        270 
LERQGFEARL LPVPGGMGPI LIAKLMENLA QAARQKR

« Hide

References

[1]"Complete sequence of Syntrophomonas wolfei subsp. wolfei str. Goettingen."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Sims D., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Goettingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000448 Genomic DNA. Translation: ABI67899.1.
RefSeqYP_753270.1. NC_008346.1.

3D structure databases

ProteinModelPortalQ0AZF5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0AZF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4281407.
GenomeReviewsGene locus Swol_0566 in contig CP000448_GR.
KEGGswo:Swol_0566.
PATRIC23855865. VBISynWol51738_0600.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHBG328751.
OMAPLATIMI.
ProtClustDBCLSK2780267.

Enzyme and pathway databases

BioCycSWOL335541:SWOL_0566-MONOMER.

Family and domain databases

HAMAPMF_01576. THF_DHG_CYH.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD1_SYNWW
AccessionPrimary (citable) accession number: Q0AZF5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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