Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0AZE0

- NADK_SYNWW

UniProt

Q0AZE0 - NADK_SYNWW

Protein

NAD kinase

Gene

nadK

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551Proton acceptorUniRule annotation
    Binding sitei60 – 601NADUniRule annotation
    Binding sitei156 – 1561NADUniRule annotation
    Binding sitei158 – 1581NADUniRule annotation
    Binding sitei193 – 1931NAD; via carbonyl oxygenUniRule annotation
    Binding sitei227 – 2271NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi55 – 562NADUniRule annotation
    Nucleotide bindingi129 – 1302NADUniRule annotation
    Nucleotide bindingi169 – 1746NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOL335541:GHL1-603-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Swol_0584
    OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
    Taxonomic identifieri335541 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
    ProteomesiUP000001968: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268NAD kinasePRO_1000059883Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335541.Swol_0584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AZE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiPRKTKFV.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0AZE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIILVNNRF KENTEKKAQE IAGQLSALNV EVIIDNGLDE PYAGTVDFIM    50
    VLGGDGTMLR AARRYGQRAI PVLGVNMGTV GFLSNIEINE LAEYLPLILR 100
    EEYSLEARMM LEVAVFQQQS LLTRVFCLNE LLLRSNSPRM LSFALEISGQ 150
    KLEPYRGDGL IVSTTTGSTA YSLSAGGPIA DPQLDAFIVT PVASHIINKR 200
    PLVVSPEREI SLHLLEEREA IIGIDGQIKM DFGAENRVLI KRAPHPLLMV 250
    NLKAKPFFTS IDRSLQRQ 268
    Length:268
    Mass (Da):29,721
    Last modified:October 17, 2006 - v1
    Checksum:i243D7467E040B314
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI67914.1.
    RefSeqiYP_753285.1. NC_008346.1.

    Genome annotation databases

    EnsemblBacteriaiABI67914; ABI67914; Swol_0584.
    GeneIDi4282681.
    KEGGiswo:Swol_0584.
    PATRICi23855899. VBISynWol51738_0617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI67914.1 .
    RefSeqi YP_753285.1. NC_008346.1.

    3D structure databases

    ProteinModelPortali Q0AZE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335541.Swol_0584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI67914 ; ABI67914 ; Swol_0584 .
    GeneIDi 4282681.
    KEGGi swo:Swol_0584.
    PATRICi 23855899. VBISynWol51738_0617.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi PRKTKFV.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SWOL335541:GHL1-603-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
      Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
      Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2245B / Goettingen.

    Entry informationi

    Entry nameiNADK_SYNWW
    AccessioniPrimary (citable) accession number: Q0AZE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3