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Q0AYH7

- DUT_SYNWW

UniProt

Q0AYH7 - DUT_SYNWW

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781SubstrateUniRule annotation
    Binding sitei92 – 921Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSWOL335541:GHL1-931-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:Swol_0911
    OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
    Taxonomic identifieri335541 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
    ProteomesiUP000001968: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000076075Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335541.Swol_0911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AYH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 673Substrate bindingUniRule annotation
    Regioni82 – 843Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028966.
    KOiK01520.
    OMAiMDLRANI.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0AYH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLFNRLHS HDLPLPRYMT PGSSGLDLYA AVDEEILIPS GKIVLVPTGL    50
    ALAIPEGYEA QIRPRSGLAL KYGITLLNTP GTIDADYRGE IKVIVINLGD 100
    KDYILKRGER IAQMVFSRVE KAEFMEVKSL DETLRGAGGF GHTGI 145
    Length:145
    Mass (Da):15,881
    Last modified:October 17, 2006 - v1
    Checksum:iFDFC2662C68E155A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68227.1.
    RefSeqiWP_011640332.1. NC_008346.1.
    YP_753598.1. NC_008346.1.

    Genome annotation databases

    EnsemblBacteriaiABI68227; ABI68227; Swol_0911.
    GeneIDi4281134.
    KEGGiswo:Swol_0911.
    PATRICi23856587. VBISynWol51738_0961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68227.1 .
    RefSeqi WP_011640332.1. NC_008346.1.
    YP_753598.1. NC_008346.1.

    3D structure databases

    ProteinModelPortali Q0AYH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335541.Swol_0911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI68227 ; ABI68227 ; Swol_0911 .
    GeneIDi 4281134.
    KEGGi swo:Swol_0911.
    PATRICi 23856587. VBISynWol51738_0961.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028966.
    KOi K01520.
    OMAi MDLRANI.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci SWOL335541:GHL1-931-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
      Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
      Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2245B / Goettingen.

    Entry informationi

    Entry nameiDUT_SYNWW
    AccessioniPrimary (citable) accession number: Q0AYH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3