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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOL335541:G1G78-944-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Swol_0930
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
Proteomesi
  • UP000001968 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677791 – 495Glutamate--tRNA ligase 1Add BLAST495

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi335541.Swol_0930

Structurei

3D structure databases

ProteinModelPortaliQ0AYF8
SMRiQ0AYF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi251 – 255"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q0AYF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIRVRFAP SPTGALHMGG ARTALFNWLF ARQNGGKFIL RIEDTDFRRS
60 70 80 90 100
REDSAQGIVE GLSWLGLDWD EGPDIGGPLG PYRQSERGDI YSRYLQELLD
110 120 130 140 150
SGQAYYCFCS PEDLQKEREE AAQEKRDYKY GGRCKALKPE EASEMLQAGK
160 170 180 190 200
PAVIRLKVPL DGNTVVPDLI RGDVSFSNAL FDDFIIAKSD GWPTYNFAVV
210 220 230 240 250
VDDFSMQISH VLRAEEHLSN TPRQLLIYRA LGLKEPAFAH LSMILAPDRS
260 270 280 290 300
KLSKRHGAIS VQEFENQGYL PEALVNYLAL LGWSTGKDID IWSREEMMRE
310 320 330 340 350
FSLEHISKSP AIYDLEKLAW MNGQYMMRLD IESLMALVEP QAQQQGWLNE
360 370 380 390 400
DNFDYFQQAV ELVRNRAKTR DELLDALGYF FEEVKQYDEK GVKKHFGQQK
410 420 430 440 450
ASTMLSEVLE IVSNMGSFSA AELEEAFRQR AQELKIKAAD LIHPTRLALS
460 470 480 490
GRTATPGLFE LMEVLGQEKC ISRLEKALDF IAKLTTHGPE GHNHR
Length:495
Mass (Da):56,202
Last modified:October 17, 2006 - v1
Checksum:i57C99098C4D511CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA Translation: ABI68246.1
RefSeqiWP_011640351.1, NC_008346.1

Genome annotation databases

EnsemblBacteriaiABI68246; ABI68246; Swol_0930
KEGGiswo:Swol_0930

Similar proteinsi

Entry informationi

Entry nameiSYE1_SYNWW
AccessioniPrimary (citable) accession number: Q0AYF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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