Q0AXC8 (KHSE_SYNWW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Swol_1318

Organism

Syntrophomonas wolfei subsp. wolfei (strain Goettingen) [Complete proteome] [HAMAP]

Taxonomic identifier

335541 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophomonas

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Homoserine kinase HAMAP MF_00384		PRO_1000049189
Regions
	Nucleotide binding	88 – 98	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0AXC8 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: FA36237375BADE59	FASTA	300	32,610
	10 20 30 40 50 60 MFTVKVPATS ANLGPGFDTL GLALQLYLEL KVTIIPQSTR IRFFVDGEEY PEEIFGDNLV 70 80 90 100 110 120 YQAMKKVFAE AAVVEAPGLE LTINSSIPPG KGLGSSAAAI VAGLYAANEI LEKRFTQEDL 130 140 150 160 170 180 ISWAVEMEGH ADNVVPAVAG GLTTAMLYRG NVYYQQFTFP PELKLVVAVP DIQISTDESR 190 200 210 220 230 240 QLLPKKIDFM DMVNNLQRAS YLLASLIKHD FRYLPAAMDD VIFQPRRKQL IPGFDRVFSQ 250 260 270 280 290 300 ALGNGAVGVA LSGSGSSIIA FCQQEEKRVA EAMQDAFAAS GIQSQLMILA ADPDGVKVLR

References

[1]

"Complete sequence of Syntrophomonas wolfei subsp. wolfei str. Goettingen." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Sims D., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Goettingen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000448 Genomic DNA. Translation: ABI68626.1.
RefSeq	YP_753997.1. NC_008346.1.
3D structure databases
ProteinModelPortal	Q0AXC8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AXC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4281898.
GenomeReviews	Gene locus Swol_1318 in contig CP000448_GR.
KEGG	swo:Swol_1318.
PATRIC	23857511. VBISynWol51738_1406.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0083.
HOGENOM	HBG646290.
OMA	NNALMST.
PhylomeDB	Q0AXC8.
Enzyme and pathway databases
BioCyc	SWOL335541:SWOL_1318-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_SYNWW

Accession

Primary (citable) accession number: Q0AXC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program