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Q0AX38 (FTHS_SYNWW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Swol_1409
OrganismSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) [Complete proteome] [HAMAP]
Taxonomic identifier335541 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300551

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0AX38 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: FCDEFF5E102A9BFA

FASTA55559,492
        10         20         30         40         50         60 
MKTDVEIAQS AKMQPITEIA DRIGIEPNEL ELYGSYKAKI SLDIMKRIED KPQGKLVLVT 

        70         80         90        100        110        120 
AISPTPAGEG KTTTTIGLGQ ALNKIGKKAI VALREPSLGP VFGIKGGATG GGYAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDI HAVTTAHNLL AALMDNHLHQ GNELDIDSRQ IVWRRVMDLN ERVLRNIVLG 

       190        200        210        220        230        240 
LGGRINGVPR ESGFDISVAS EVMAALCLAT DLMDLKERFA KIVVAYSQQG QAITAGDLKA 

       250        260        270        280        290        300 
AGSMALLMKD AIKPNLVQTL ENTPAFIHGG PFANIAHGAN SIVATRLGVK LADYMVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FNIVCRYGKL VPDAVVLVAS IRALKHHGGV KKDKLGEENL EALAQGMENL 

       370        380        390        400        410        420 
KKHLENIQKF GVPAVVALNE FPSDTSKEID YVFSQCAAMQ TAVSISRVWA QGGEGGIDLA 

       430        440        450        460        470        480 
EKLVLATEQG SQFKFLYELN QPLKNKIETI CREIYGAGSV KYAAEAKRML QKYEESGFGD 

       490        500        510        520        530        540 
LPVCIAKTQY SLSDNAQLLG RPTGFEVNIR QVKLSAGAGF VVALAGDIMT MPGLGKVPAA 

       550 
ENIDIKPDGE IVGLF 

« Hide

References

[1]"The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2245B / Goettingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000448 Genomic DNA. Translation: ABI68716.1.
RefSeqYP_754087.1. NC_008346.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335541.Swol_1409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI68716; ABI68716; Swol_1409.
GeneID4282713.
KEGGswo:Swol_1409.
PATRIC23857719. VBISynWol51738_1510.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSWOL335541:GHL1-1451-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SYNWW
AccessionPrimary (citable) accession number: Q0AX38
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways