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Q0AX38

- FTHS_SYNWW

UniProt

Q0AX38 - FTHS_SYNWW

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Swol_1409
Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOL335541:GHL1-1451-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Swol_1409
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
ProteomesiUP000001968: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300551Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335541.Swol_1409.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AX38-1 [UniParc]FASTAAdd to Basket

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MKTDVEIAQS AKMQPITEIA DRIGIEPNEL ELYGSYKAKI SLDIMKRIED    50
KPQGKLVLVT AISPTPAGEG KTTTTIGLGQ ALNKIGKKAI VALREPSLGP 100
VFGIKGGATG GGYAQVVPME DINLHFTGDI HAVTTAHNLL AALMDNHLHQ 150
GNELDIDSRQ IVWRRVMDLN ERVLRNIVLG LGGRINGVPR ESGFDISVAS 200
EVMAALCLAT DLMDLKERFA KIVVAYSQQG QAITAGDLKA AGSMALLMKD 250
AIKPNLVQTL ENTPAFIHGG PFANIAHGAN SIVATRLGVK LADYMVTEAG 300
FGADLGAEKF FNIVCRYGKL VPDAVVLVAS IRALKHHGGV KKDKLGEENL 350
EALAQGMENL KKHLENIQKF GVPAVVALNE FPSDTSKEID YVFSQCAAMQ 400
TAVSISRVWA QGGEGGIDLA EKLVLATEQG SQFKFLYELN QPLKNKIETI 450
CREIYGAGSV KYAAEAKRML QKYEESGFGD LPVCIAKTQY SLSDNAQLLG 500
RPTGFEVNIR QVKLSAGAGF VVALAGDIMT MPGLGKVPAA ENIDIKPDGE 550
IVGLF 555
Length:555
Mass (Da):59,492
Last modified:October 17, 2006 - v1
Checksum:iFCDEFF5E102A9BFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000448 Genomic DNA. Translation: ABI68716.1.
RefSeqiWP_011640815.1. NC_008346.1.
YP_754087.1. NC_008346.1.

Genome annotation databases

EnsemblBacteriaiABI68716; ABI68716; Swol_1409.
GeneIDi4282713.
KEGGiswo:Swol_1409.
PATRICi23857719. VBISynWol51738_1510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000448 Genomic DNA. Translation: ABI68716.1 .
RefSeqi WP_011640815.1. NC_008346.1.
YP_754087.1. NC_008346.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335541.Swol_1409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI68716 ; ABI68716 ; Swol_1409 .
GeneIDi 4282713.
KEGGi swo:Swol_1409.
PATRICi 23857719. VBISynWol51738_1510.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SWOL335541:GHL1-1451-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
    Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
    Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2245B / Goettingen.

Entry informationi

Entry nameiFTHS_SYNWW
AccessioniPrimary (citable) accession number: Q0AX38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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