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Q0AX38

- FTHS_SYNWW

UniProt

Q0AX38 - FTHS_SYNWW

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOL335541:GHL1-1451-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Swol_1409
    OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
    Taxonomic identifieri335541 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
    ProteomesiUP000001968: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000300551Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335541.Swol_1409.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0AX38-1 [UniParc]FASTAAdd to Basket

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    MKTDVEIAQS AKMQPITEIA DRIGIEPNEL ELYGSYKAKI SLDIMKRIED    50
    KPQGKLVLVT AISPTPAGEG KTTTTIGLGQ ALNKIGKKAI VALREPSLGP 100
    VFGIKGGATG GGYAQVVPME DINLHFTGDI HAVTTAHNLL AALMDNHLHQ 150
    GNELDIDSRQ IVWRRVMDLN ERVLRNIVLG LGGRINGVPR ESGFDISVAS 200
    EVMAALCLAT DLMDLKERFA KIVVAYSQQG QAITAGDLKA AGSMALLMKD 250
    AIKPNLVQTL ENTPAFIHGG PFANIAHGAN SIVATRLGVK LADYMVTEAG 300
    FGADLGAEKF FNIVCRYGKL VPDAVVLVAS IRALKHHGGV KKDKLGEENL 350
    EALAQGMENL KKHLENIQKF GVPAVVALNE FPSDTSKEID YVFSQCAAMQ 400
    TAVSISRVWA QGGEGGIDLA EKLVLATEQG SQFKFLYELN QPLKNKIETI 450
    CREIYGAGSV KYAAEAKRML QKYEESGFGD LPVCIAKTQY SLSDNAQLLG 500
    RPTGFEVNIR QVKLSAGAGF VVALAGDIMT MPGLGKVPAA ENIDIKPDGE 550
    IVGLF 555
    Length:555
    Mass (Da):59,492
    Last modified:October 17, 2006 - v1
    Checksum:iFCDEFF5E102A9BFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68716.1.
    RefSeqiWP_011640815.1. NC_008346.1.
    YP_754087.1. NC_008346.1.

    Genome annotation databases

    EnsemblBacteriaiABI68716; ABI68716; Swol_1409.
    GeneIDi4282713.
    KEGGiswo:Swol_1409.
    PATRICi23857719. VBISynWol51738_1510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68716.1 .
    RefSeqi WP_011640815.1. NC_008346.1.
    YP_754087.1. NC_008346.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335541.Swol_1409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI68716 ; ABI68716 ; Swol_1409 .
    GeneIDi 4282713.
    KEGGi swo:Swol_1409.
    PATRICi 23857719. VBISynWol51738_1510.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SWOL335541:GHL1-1451-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
      Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
      Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2245B / Goettingen.

    Entry informationi

    Entry nameiFTHS_SYNWW
    AccessioniPrimary (citable) accession number: Q0AX38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3