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Protein

Glycine--tRNA ligase alpha subunit

Gene

glyQ

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOL335541:GHL1-1561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.14UniRule annotation)
Alternative name(s):
Glycyl-tRNA synthetase alpha subunitUniRule annotation
Short name:
GlyRSUniRule annotation
Gene namesi
Name:glyQUniRule annotation
Ordered Locus Names:Swol_1516
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
Proteomesi
  • UP000001968 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Glycine--tRNA ligase alpha subunitPRO_1000047521Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi335541.Swol_1516.

Structurei

3D structure databases

ProteinModelPortaliQ0AWT5.
SMRiQ0AWT5. Positions 1-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HMW. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AWT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFQELILRL HNFWGQQGCI IQQPYDVEKG AGTMNPATFL RALGPEPWKV
60 70 80 90 100
AYVEPSRRPT DGRYGENPNR LQHYYQYQVI LKPSPDNVID LYLASLRDLG
110 120 130 140 150
IEPEKHDIRL VEDNWESPTL GAWGLGWEIW LDGMEITQFT YFQQCGGFDC
160 170 180 190 200
LPVSAEITYG IERIAMYIQN KESVFDIEWV DGISYADVHH QAEVDYSHYN
210 220 230 240 250
FEAADVGALT SMFNICEEEA IRVAERQLVQ PAYDYVLKCS HLFNLLDARG
260 270 280 290 300
AISVTERTAY IGRVRNLARM VAREYLEQRK RLNYPLLKDE KLRKQLIIEE

EVL
Length:303
Mass (Da):35,192
Last modified:October 17, 2006 - v1
Checksum:iA27BBE1859DFDFCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA. Translation: ABI68819.1.
RefSeqiWP_011640918.1. NC_008346.1.

Genome annotation databases

EnsemblBacteriaiABI68819; ABI68819; Swol_1516.
KEGGiswo:Swol_1516.
PATRICi23857955. VBISynWol51738_1624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA. Translation: ABI68819.1.
RefSeqiWP_011640918.1. NC_008346.1.

3D structure databases

ProteinModelPortaliQ0AWT5.
SMRiQ0AWT5. Positions 1-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335541.Swol_1516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI68819; ABI68819; Swol_1516.
KEGGiswo:Swol_1516.
PATRICi23857955. VBISynWol51738_1624.

Phylogenomic databases

eggNOGiENOG4108HMW. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Enzyme and pathway databases

BioCyciSWOL335541:GHL1-1561-MONOMER.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYGA_SYNWW
AccessioniPrimary (citable) accession number: Q0AWT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.