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Q0AWK4

- SYL_SYNWW

UniProt

Q0AWK4 - SYL_SYNWW

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOL335541:GHL1-1645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Swol_1599
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
ProteomesiUP000001968: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligasePRO_0000334833Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335541.Swol_1599.

Structurei

3D structure databases

ProteinModelPortaliQ0AWK4.
SMRiQ0AWK4. Positions 1-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AWK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRKYDFKSI EAKWQAYWEN KQLFKVEEDP EKPKYYNLEM FPYPSGHLHM
60 70 80 90 100
GHVRNYAIGD VVARFKSMNG FNVLHPMGWD AFGLPAENAA IKNAIHPATW
110 120 130 140 150
TYSNIENMKR QLKTMGISYD WDRELATCKP DYYKFTQWMF LKLYENKLAY
160 170 180 190 200
KKKSAVNWCP SCQTVLANEQ VVDGACERCE AVIEKKQLEQ WFFKITDYAQ
210 220 230 240 250
RLLDDLALLP GWPEKVKTMQ KNWIGRSEGC EFSLHIEDSD EVLTVFTTRP
260 270 280 290 300
DTVFGVTYMV LAPEHPLVEK ICHPEQEKEV KAFVNKMKYL NEMARTSTEA
310 320 330 340 350
EKEGVFTGAY AINPMDGSRI PIWIANYVLM DYGTGAIMAV PAHDQRDFEF
360 370 380 390 400
ARKYDIPVKV VIKGEDTPLD GNLLQESYPG DGHMVNSGNF DGLTVEEGQK
410 420 430 440 450
AVIKFMEEKG IGQGTVNYRL RDWLISRQRY WGAPIPIVYC PECGPVAVPE
460 470 480 490 500
EELPLYLPED IDFKPYAESP LKHLERFYKT TCPSCGKEAL RETDTMDTFV
510 520 530 540 550
CSSWYFDRFC SPHESKQPFS REAVDYWMPV DQYIGGVEHA ILHLMYARFF
560 570 580 590 600
TKFLFDINVL SCQEPFTRLL TQGMVLKDNA KMSKSKGNVV SPEEIIDTYG
610 620 630 640 650
ADTARLFILF ASPPERDLEW SEQGVEGAFR FLNRVWRLVS ELAEGIKDLP
660 670 680 690 700
AAEHFPELDS EAKNLRFKTH ATIKKVTEDI GERFNFNTAI SAIMELSNTL
710 720 730 740 750
GAYKGIKKPN WPVVKEAVDN LLILLSPFSP HICEELWQLT GHAESIYLQK
760 770 780 790 800
WPKYDPEALL QEEIEIVLQI SGKVRDRIMV PVDAGREELE KIALDNPKIR
810 820
ELTRGKEIVK LIVVPGKLVN VVAK
Length:824
Mass (Da):94,728
Last modified:October 17, 2006 - v1
Checksum:iBDD2B77DF3ADA95E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA. Translation: ABI68900.1.
RefSeqiWP_011640998.1. NC_008346.1.
YP_754271.1. NC_008346.1.

Genome annotation databases

EnsemblBacteriaiABI68900; ABI68900; Swol_1599.
GeneIDi4283694.
KEGGiswo:Swol_1599.
PATRICi23858145. VBISynWol51738_1718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000448 Genomic DNA. Translation: ABI68900.1 .
RefSeqi WP_011640998.1. NC_008346.1.
YP_754271.1. NC_008346.1.

3D structure databases

ProteinModelPortali Q0AWK4.
SMRi Q0AWK4. Positions 1-759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335541.Swol_1599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI68900 ; ABI68900 ; Swol_1599 .
GeneIDi 4283694.
KEGGi swo:Swol_1599.
PATRICi 23858145. VBISynWol51738_1718.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SWOL335541:GHL1-1645-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
    Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
    Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2245B / Goettingen.

Entry informationi

Entry nameiSYL_SYNWW
AccessioniPrimary (citable) accession number: Q0AWK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3