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Q0AWK4

- SYL_SYNWW

UniProt

Q0AWK4 - SYL_SYNWW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOL335541:GHL1-1645-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Swol_1599
    OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
    Taxonomic identifieri335541 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
    ProteomesiUP000001968: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_0000334833Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335541.Swol_1599.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AWK4.
    SMRiQ0AWK4. Positions 1-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0AWK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRKYDFKSI EAKWQAYWEN KQLFKVEEDP EKPKYYNLEM FPYPSGHLHM    50
    GHVRNYAIGD VVARFKSMNG FNVLHPMGWD AFGLPAENAA IKNAIHPATW 100
    TYSNIENMKR QLKTMGISYD WDRELATCKP DYYKFTQWMF LKLYENKLAY 150
    KKKSAVNWCP SCQTVLANEQ VVDGACERCE AVIEKKQLEQ WFFKITDYAQ 200
    RLLDDLALLP GWPEKVKTMQ KNWIGRSEGC EFSLHIEDSD EVLTVFTTRP 250
    DTVFGVTYMV LAPEHPLVEK ICHPEQEKEV KAFVNKMKYL NEMARTSTEA 300
    EKEGVFTGAY AINPMDGSRI PIWIANYVLM DYGTGAIMAV PAHDQRDFEF 350
    ARKYDIPVKV VIKGEDTPLD GNLLQESYPG DGHMVNSGNF DGLTVEEGQK 400
    AVIKFMEEKG IGQGTVNYRL RDWLISRQRY WGAPIPIVYC PECGPVAVPE 450
    EELPLYLPED IDFKPYAESP LKHLERFYKT TCPSCGKEAL RETDTMDTFV 500
    CSSWYFDRFC SPHESKQPFS REAVDYWMPV DQYIGGVEHA ILHLMYARFF 550
    TKFLFDINVL SCQEPFTRLL TQGMVLKDNA KMSKSKGNVV SPEEIIDTYG 600
    ADTARLFILF ASPPERDLEW SEQGVEGAFR FLNRVWRLVS ELAEGIKDLP 650
    AAEHFPELDS EAKNLRFKTH ATIKKVTEDI GERFNFNTAI SAIMELSNTL 700
    GAYKGIKKPN WPVVKEAVDN LLILLSPFSP HICEELWQLT GHAESIYLQK 750
    WPKYDPEALL QEEIEIVLQI SGKVRDRIMV PVDAGREELE KIALDNPKIR 800
    ELTRGKEIVK LIVVPGKLVN VVAK 824
    Length:824
    Mass (Da):94,728
    Last modified:October 17, 2006 - v1
    Checksum:iBDD2B77DF3ADA95E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68900.1.
    RefSeqiYP_754271.1. NC_008346.1.

    Genome annotation databases

    EnsemblBacteriaiABI68900; ABI68900; Swol_1599.
    GeneIDi4283694.
    KEGGiswo:Swol_1599.
    PATRICi23858145. VBISynWol51738_1718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000448 Genomic DNA. Translation: ABI68900.1 .
    RefSeqi YP_754271.1. NC_008346.1.

    3D structure databases

    ProteinModelPortali Q0AWK4.
    SMRi Q0AWK4. Positions 1-759.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335541.Swol_1599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI68900 ; ABI68900 ; Swol_1599 .
    GeneIDi 4283694.
    KEGGi swo:Swol_1599.
    PATRICi 23858145. VBISynWol51738_1718.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SWOL335541:GHL1-1645-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
      Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
      Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2245B / Goettingen.

    Entry informationi

    Entry nameiSYL_SYNWW
    AccessioniPrimary (citable) accession number: Q0AWK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3