Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0AW31

- PUR9_SYNWW

UniProt

Q0AW31 - PUR9_SYNWW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSWOL335541:GHL1-1828-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Swol_1775
OrganismiSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
Taxonomic identifieri335541 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas
ProteomesiUP000001968: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Bifunctional purine biosynthesis protein PurHPRO_1000018983Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335541.Swol_1775.

Structurei

3D structure databases

ProteinModelPortaliQ0AW31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AW31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRALISVSN KEGLLDFARG LEKLGYEIIS TGGTYNTIKE AGIKVKKVAD
60 70 80 90 100
ITGFPEILDG RVKTLHPKIH GGILARRIPE HLQQLQENDI GPIDIVAVNL
110 120 130 140 150
YPFRETISRP GVSLEEAIEN IDIGGPAMVR AAAKNYQDVA VVVKPEFYQA
160 170 180 190 200
LLEALEKPGG ISPEFRLKLA LEAFSHTAAY DAMISSYLSR VSNSDLNQNL
210 220 230 240 250
ILAGEKVYDL RYGENPHQKA SFYRFMTPGL GLPDARQLNG KELSYNNIID
260 270 280 290 300
TQAAWELVRE FDEPACVIIK HTNPCGTAVA ATLEEAFDRA FAADPLSAFG
310 320 330 340 350
GIIALNRPVD GATAQKAAEP FMEVIIAPAY TPEALESLQA KKNLRVLELP
360 370 380 390 400
LEVAGGLQIR TVAGGFVVQE SDRDKLDMDK VQVVTQKEPT VEQLKELAFA
410 420 430 440 450
RKVVKHIKSN AIVVARDGMT LGVGAGQMNR VGSARIALES AGEKARGAVM
460 470 480 490 500
ASDAFFPFKD TVELAAQYGI TAIIQPGGSV RDQESIDECD KHGIAMVFTG

IRHFKH
Length:506
Mass (Da):55,047
Last modified:October 17, 2006 - v1
Checksum:i9BA05C7BBBBD9459
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000448 Genomic DNA. Translation: ABI69073.1.
RefSeqiWP_011641168.1. NC_008346.1.
YP_754444.1. NC_008346.1.

Genome annotation databases

EnsemblBacteriaiABI69073; ABI69073; Swol_1775.
GeneIDi4282737.
KEGGiswo:Swol_1775.
PATRICi23858545. VBISynWol51738_1911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000448 Genomic DNA. Translation: ABI69073.1 .
RefSeqi WP_011641168.1. NC_008346.1.
YP_754444.1. NC_008346.1.

3D structure databases

ProteinModelPortali Q0AW31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335541.Swol_1775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI69073 ; ABI69073 ; Swol_1775 .
GeneIDi 4282737.
KEGGi swo:Swol_1775.
PATRICi 23858545. VBISynWol51738_1911.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SWOL335541:GHL1-1828-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
    Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
    Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2245B / Goettingen.

Entry informationi

Entry nameiPUR9_SYNWW
AccessioniPrimary (citable) accession number: Q0AW31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3