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Q0AVH9 (GCSPB_SYNWW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:Swol_1980
OrganismSyntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) [Complete proteome] [HAMAP]
Taxonomic identifier335541 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophomonas

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_1000083235

Amino acid modifications

Modified residue2691N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0AVH9 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 071C008DEAAD060A

FASTA48653,556
        10         20         30         40         50         60 
MSKVIFARSV AGGGGFFLPP CDVAEIEPAA EINPEFLRAE APLLPELSEV EVVRHYVELS 

        70         80         90        100        110        120 
QRAYGVDNGF YPLGSCTMKY NPKINEWAAR LPGFANLHPY QPEESVQGAL ELLYRAEKLC 

       130        140        150        160        170        180 
CEIGGMDRFT LQPAAGAHGE LTGLMIIKAY HQHRQDLART KILVPDSAHG TNPATAHVLG 

       190        200        210        220        230        240 
FEVVEVKSNE EGLVDLQDLK ACMSSEVAGL MLTNPNTLGL FEKEIEEIAT VVHADGGLLY 

       250        260        270        280        290        300 
YDGANLNGIV GVARPGDMGF DVLHFNLHKT FGTPHGGGGP GSGPVGVKDF LSGFLPHPLV 

       310        320        330        340        350        360 
EKKEEGYYLD YDRPLSIGKV RSFYGNFGVI VKAYAYMMAL GGPGLREACE LAVLNSNYLR 

       370        380        390        400        410        420 
HHLQEDYHIP FNRLCKHEFV ASGQKQLAEN GVSTLDIAKR LMDYGFHPPT VYFPLIVKEA 

       430        440        450        460        470        480 
LMIEPVETES RERLDEFIAA MREIAREARE NPDILHQAPH STVIKRVDEV RAARQPILRW 


PGLGAE 

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References

[1]"The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production."
Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L., McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.
Environ. Microbiol. 12:2289-2301(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2245B / Goettingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000448 Genomic DNA. Translation: ABI69275.1.
RefSeqYP_754646.1. NC_008346.1.

3D structure databases

ProteinModelPortalQ0AVH9.
SMRQ0AVH9. Positions 3-481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335541.Swol_1980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI69275; ABI69275; Swol_1980.
GeneID4283337.
KEGGswo:Swol_1980.
PATRIC23859003. VBISynWol51738_2139.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAMHINLHK.
OrthoDBEOG6HMXDX.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycSWOL335541:GHL1-2034-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_SYNWW
AccessionPrimary (citable) accession number: Q0AVH9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families