Q0ATD8 (MSRA_MARMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	Mmar10_0153

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000068338
Sites
	Active site	54	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0ATD8 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 68564BC86C7F562E	FASTA	217	23,457
	10 20 30 40 50 60 MSDPIWKSRI IPAEQALPGR ADALSPTTSH AITGREIKAD TPEGMQEIFL GLGCFWGAER 70 80 90 100 110 120 LFWETDGVWH TAVGYGGGTT PNPTYQETCS GATGHAELVR VVFDPEMLSL DQVLKIFWEG 130 140 150 160 170 180 HDPTQGMRQG NDRGTQYRSA IYATTPEQLV AAHDAAARYQ AELDGAGLGT ITTEIVKAGP 190 200 210 FYYAEDEHQQ YLARNPSGYC GIGGTGVVCP IGRHAPT

References

[1]

"Complete sequence of Maricaulis maris MCS10." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000449 Genomic DNA. Translation: ABI64449.1.
RefSeq	YP_755387.1. NC_008347.1.
3D structure databases
ProteinModelPortal	Q0ATD8.
SMR	Q0ATD8. Positions 12-210.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0ATD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4285518.
GenomeReviews	Gene locus Mmar10_0153 in contig CP000449_GR.
KEGG	mmr:Mmar10_0153.
NMPDR	fig|394221.5.peg.157.
PATRIC	22448298. VBIMarMar77530_0160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	SAIYCTS.
PhylomeDB	Q0ATD8.
Enzyme and pathway databases
BioCyc	MMAR394221:MMAR10_0153-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_MARMM

Accession

Primary (citable) accession number: Q0ATD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program