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Q0ASU7

- Q0ASU7_MARMM

UniProt

Q0ASU7 - Q0ASU7_MARMM

Protein
Submitted name:

Uroporphyrin-III C-methyltransferase

Gene

Mmar10_0347

Organism
Maricaulis maris (strain MCS10)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.SAAS annotation

    Catalytic activityi

    Precorrin-2 + NAD+ = sirohydrochlorin + NADH.SAAS annotation
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.SAAS annotation
    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.SAAS annotation
    Siroheme + 2 H+ = sirohydrochlorin + Fe2+.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. precorrin-2 dehydrogenase activity Source: InterPro
    3. sirohydrochlorin ferrochelatase activity Source: InterPro
    4. uroporphyrin-III C-methyltransferase activity Source: InterPro

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. siroheme biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseSAAS annotation, MethyltransferaseUniRule annotationSAAS annotationImported, OxidoreductaseSAAS annotation, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesisSAAS annotation, Porphyrin biosynthesisSAAS annotation

    Keywords - Ligandi

    NADSAAS annotation, S-adenosyl-L-methionineSAAS annotation

    Enzyme and pathway databases

    BioCyciMMAR394221:GHNB-353-MONOMER.
    UniPathwayiUPA00148; UER00211.
    UPA00148; UER00222.
    UPA00262; UER00211.
    UPA00262; UER00222.
    UPA00262; UER00376.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uroporphyrin-III C-methyltransferaseImported
    Gene namesi
    Ordered Locus Names:Mmar10_0347Imported
    OrganismiMaricaulis maris (strain MCS10)Imported
    Taxonomic identifieri394221 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
    ProteomesiUP000001964: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi394221.Mmar10_0347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0ASU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000290518.
    KOiK02302.
    OMAiPANAMID.
    OrthoDBiEOG6DRPFR.

    Family and domain databases

    Gene3Di1.10.8.210. 1 hit.
    3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR012409. Sirohaem_synth.
    IPR019478. Sirohaem_synthase_dimer_dom.
    IPR006367. Sirohaem_synthase_N.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF10414. CysG_dimeriser. 1 hit.
    PF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036426. Sirohaem_synth. 1 hit.
    SUPFAMiSSF53790. SSF53790. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    TIGR01470. cysG_Nterm. 1 hit.
    PROSITEiPS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0ASU7-1 [UniParc]FASTAAdd to Basket

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    MRVFPASIPL DGQTVIVVGQ GPMAEPKARL FASSPARLLW FTGETHDPVA    50
    SDIAQYAKII RRVPTRRDFR GATLIFLAGG EDRALAKLAR WGRSQGALVN 100
    IVDSPAASDF QTPAIVDRDG IVVSIASGGA APVLSVDIRA AIEQILPARI 150
    GDIADLARGL RGTVKSVLGK FDDRRAFWER ALRGKARDLA LSGDKAGARR 200
    EMLRELNGET SARAGIVHLV GAGPGDPDLL TLKAARLLRE ADVIVHDRLV 250
    SQGVMDLARR DALRIDVGKT KGHHPVPQEQ IGEILVREAR KGQRVVRIKG 300
    GDPFVFGRGG EELDVVRAAG IKAEVTPGIT AAVACAASAG IPLTHRDHAQ 350
    SVTFASGVVK QDGPDADYRA LSAPNSTTVF YMGVGAAPDI QAKMIEAGRD 400
    PATPVALVEN GTLDTERRVF GTLGDLAALV EREAISGPTI MIVGEVAGAA 450
    LTSARASAGQ EQFA 464
    Length:464
    Mass (Da):48,907
    Last modified:October 17, 2006 - v1
    Checksum:i5E0A46082AFB64EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI64640.1.
    RefSeqiYP_755578.1. NC_008347.1.

    Genome annotation databases

    EnsemblBacteriaiABI64640; ABI64640; Mmar10_0347.
    GeneIDi4285499.
    KEGGimmr:Mmar10_0347.
    PATRICi22448674. VBIMarMar77530_0347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI64640.1 .
    RefSeqi YP_755578.1. NC_008347.1.

    3D structure databases

    ProteinModelPortali Q0ASU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394221.Mmar10_0347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI64640 ; ABI64640 ; Mmar10_0347 .
    GeneIDi 4285499.
    KEGGi mmr:Mmar10_0347.
    PATRICi 22448674. VBIMarMar77530_0347.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000290518.
    KOi K02302.
    OMAi PANAMID.
    OrthoDBi EOG6DRPFR.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00211 .
    UPA00148 ; UER00222 .
    UPA00262 ; UER00211 .
    UPA00262 ; UER00222 .
    UPA00262 ; UER00376 .
    BioCyci MMAR394221:GHNB-353-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.210. 1 hit.
    3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR012409. Sirohaem_synth.
    IPR019478. Sirohaem_synthase_dimer_dom.
    IPR006367. Sirohaem_synthase_N.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF10414. CysG_dimeriser. 1 hit.
    PF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036426. Sirohaem_synth. 1 hit.
    SUPFAMi SSF53790. SSF53790. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    TIGR01470. cysG_Nterm. 1 hit.
    PROSITEi PS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MCS10Imported.

    Entry informationi

    Entry nameiQ0ASU7_MARMM
    AccessioniPrimary (citable) accession number: Q0ASU7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3