truA

Functionⁱ

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityⁱ

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	52	NucleophileUniRule annotation		1
Binding siteⁱ	111	SubstrateUniRule annotation		1

GO - Molecular functionⁱ

pseudouridine synthase activity Source: UniProtKB-EC
RNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

pseudouridine synthesis Source: InterPro
tRNA processing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	tRNA processing

Enzyme and pathway databases

BioCycⁱ	MMAR394221:G1G79-464-MONOMER

BioCycⁱ

MMAR394221:G1G79-464-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation) Alternative name(s): tRNA pseudouridine(38-40) synthaseUniRule annotation tRNA pseudouridylate synthase IUniRule annotation tRNA-uridine isomerase IUniRule annotation
Gene namesⁱ	Name:truAUniRule annotation Ordered Locus Names:Mmar10_0447
Organismⁱ	Maricaulis maris (strain MCS10)
Taxonomic identifierⁱ	394221 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis › Maricaulis maris
Proteomesⁱ	UP000001964 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000017109	1 – 249	tRNA pseudouridine synthase AAdd BLAST		249

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	394221.Mmar10_0447

STRINGⁱ

394221.Mmar10_0447

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0ASJ7
SMRⁱ	Q0ASJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105DI7 Bacteria COG0101 LUCA
HOGENOMⁱ	HOG000248672
KEGG Orthology (KO) More...KOⁱ	K06173
OMAⁱ	FLYGMVR
Database of Orthologous Groups More...OrthoDBⁱ	POG091H010Q

Family and domain databases

Gene3Dⁱ	3.30.70.6601 hit
HAMAPⁱ	MF_00171 TruA, 1 hit
InterProⁱ	View protein in InterPro IPR020103 PsdUridine_synth_cat_dom_sf IPR001406 PsdUridine_synth_TruA IPR020097 PsdUridine_synth_TruA_a/b_dom IPR020095 PsdUridine_synth_TruA_C
PANTHERⁱ	PTHR11142 PTHR11142, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01416 PseudoU_synth_1, 2 hits
PIRSFⁱ	PIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMⁱ	SSF55120 SSF55120, 1 hit
TIGRFAMsⁱ	TIGR00071 hisT_truA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0ASJ7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRYRITIEY DGRPFSGWQR QDNAPSVQES LERAAEKLDG APVLVYGAGR 
        60         70         80         90        100
TDSGVHALAQ VAHLDLAKDL STDKVRDAIN YHLKPDPVAV IEAARVSDDF 
       110        120        130        140        150
HARFSATRRH YLYRMIDRRA PLTLDRGQVW RVTRKLDAEA MHHAAQALLG 
       160        170        180        190        200
QHDFTTFRDA QCQAESPVKS LDAISVSRYG EEVQLTCSAR SFLHRQVRSM 
       210        220        230        240 
VGSLVEVGVG KWSARDFKRA LDAADRSRCG PVAPADGLYL TAVDYPGPA

Length:249

Mass (Da):27,686

Last modified:October 17, 2006 - v1

Checksum:ⁱD200A5F742DDB9FF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000449 Genomic DNA Translation: ABI64740.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011642387.1, NC_008347.1

Genome annotation databases

EnsemblBacteriaⁱ	ABI64740; ABI64740; Mmar10_0447
KEGGⁱ	mmr:Mmar10_0447

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q0ASJ7	A0A1Q8G183	Maricaulis sp. W15	249	UniRef90_Q0ASJ7	Cluster: tRNA pseudouridine synthase A	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q0ASJ7	Q5FPX3 A0A067Z434 UPI000C06F451 UPI0007827047 A0A1U9KWQ3 A0A149TEV1 UPI000A3938E1 UPI000597661E A0A149QV09 A0A149TAR7 +316	Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) Gluconobacter oxydans DSM 3504 Gluconobacter kondonii Gluconobacter albidus Gluconobacter sp. DsW_056 Gluconobacter oxydans (Gluconobacter suboxydans) Gluconobacter roseus Rhodospirillales bacterium 70-18 Alphaproteobacteria bacterium Devosia sp. Root635 And more	275	UniRef50_Q5FPX3	Cluster: tRNA pseudouridine synthase A	327

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000449 Genomic DNA Translation: ABI64740.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011642387.1, NC_008347.1

3D structure databases

ProteinModelPortalⁱ	Q0ASJ7
SMRⁱ	Q0ASJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	394221.Mmar10_0447

STRINGⁱ

394221.Mmar10_0447

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABI64740; ABI64740; Mmar10_0447
KEGGⁱ	mmr:Mmar10_0447

Phylogenomic databases

eggNOGⁱ	ENOG4105DI7 Bacteria COG0101 LUCA
HOGENOMⁱ	HOG000248672
KEGG Orthology (KO) More...KOⁱ	K06173
OMAⁱ	FLYGMVR
Database of Orthologous Groups More...OrthoDBⁱ	POG091H010Q

Enzyme and pathway databases

BioCycⁱ	MMAR394221:G1G79-464-MONOMER

BioCycⁱ

MMAR394221:G1G79-464-MONOMER

Family and domain databases

Gene3Dⁱ	3.30.70.6601 hit
HAMAPⁱ	MF_00171 TruA, 1 hit
InterProⁱ	View protein in InterPro IPR020103 PsdUridine_synth_cat_dom_sf IPR001406 PsdUridine_synth_TruA IPR020097 PsdUridine_synth_TruA_a/b_dom IPR020095 PsdUridine_synth_TruA_C
PANTHERⁱ	PTHR11142 PTHR11142, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01416 PseudoU_synth_1, 2 hits
PIRSFⁱ	PIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMⁱ	SSF55120 SSF55120, 1 hit
TIGRFAMsⁱ	TIGR00071 hisT_truA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRUA_MARMM
Accessionⁱ	Q0ASJ7Primary (citable) accession number: Q0ASJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 17, 2006
	Last modified:	February 28, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q0ASJ7 (TRUA_MARMM)

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tRNA pseudouridine synthase A

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q0ASJ7 (TRUA_MARMM)

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tRNA pseudouridine synthase A

truA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ