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Q0ARN5

- KPRS_MARMM

UniProt

Q0ARN5 - KPRS_MARMM

Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi125 – 1251MagnesiumUniRule annotation
    Metal bindingi127 – 1271MagnesiumUniRule annotation
    Metal bindingi136 – 1361MagnesiumUniRule annotation
    Metal bindingi140 – 1401MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. kinase activity Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. ribose phosphate diphosphokinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. nucleotide biosynthetic process Source: UniProtKB-KW
    3. ribonucleoside monophosphate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR394221:GHNB-769-MONOMER.
    UniPathwayiUPA00087; UER00172.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
    Short name:
    RPPKUniRule annotation
    Alternative name(s):
    Phosphoribosyl pyrophosphate synthaseUniRule annotation
    Short name:
    P-Rib-PP synthaseUniRule annotation
    Short name:
    PRPP synthaseUniRule annotation
    Gene namesi
    Name:prsUniRule annotation
    Ordered Locus Names:Mmar10_0759
    OrganismiMaricaulis maris (strain MCS10)
    Taxonomic identifieri394221 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
    ProteomesiUP000001964: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Ribose-phosphate pyrophosphokinasePRO_1000025453Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi394221.Mmar10_0759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0ARN5.
    SMRiQ0ARN5. Positions 1-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni209 – 22214Binding of phosphoribosylpyrophosphateSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0462.
    HOGENOMiHOG000210449.
    KOiK00948.
    OMAiEVANKNC.
    OrthoDBiEOG6Z99XQ.

    Family and domain databases

    Gene3Di3.40.50.2020. 2 hits.
    HAMAPiMF_00583_B. RibP_PPkinase_B.
    InterProiIPR000842. PRib_PP_synth_CS.
    IPR029099. Pribosyltran_N.
    IPR029057. PRTase-like.
    IPR005946. Rib-P_diPkinase.
    [Graphical view]
    PfamiPF14572. Pribosyl_synth. 1 hit.
    PF13793. Pribosyltran_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
    PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0ARN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLMSGTANP DLSRSIADYL DAPLTASHIE RFADGEIFVR IDENVRGEDV    50
    FILQSTSRPA NDHLMELLIC IDALVRASAR RITAVIPYFG YARQDRKTGG 100
    RTPISAKLVA NLIAKAGADR VLTVDLHAGQ IQGFFDIPTD NLFATKVMEA 150
    DIRRHYETDN LLIVSPDVGG VVRARALAKL LDAEIAIVDK RRPKAGVAEV 200
    MNIIGEVEGR RCILFDDMCD SGGTLVNAAD ALLEKGAIEV SAYVTHGVLS 250
    KDAQGRVDKS RLRELVVTDS VTEPPNSTAT PKVRRLSVAP LLGEAIRRIA 300
    NDESVSKLFD 310
    Length:310
    Mass (Da):33,732
    Last modified:October 17, 2006 - v1
    Checksum:iEDD7EBA82C22DC19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65052.1.
    RefSeqiWP_011642699.1. NC_008347.1.
    YP_755990.1. NC_008347.1.

    Genome annotation databases

    EnsemblBacteriaiABI65052; ABI65052; Mmar10_0759.
    GeneIDi4286502.
    KEGGimmr:Mmar10_0759.
    PATRICi22449540. VBIMarMar77530_0777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65052.1 .
    RefSeqi WP_011642699.1. NC_008347.1.
    YP_755990.1. NC_008347.1.

    3D structure databases

    ProteinModelPortali Q0ARN5.
    SMRi Q0ARN5. Positions 1-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394221.Mmar10_0759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI65052 ; ABI65052 ; Mmar10_0759 .
    GeneIDi 4286502.
    KEGGi mmr:Mmar10_0759.
    PATRICi 22449540. VBIMarMar77530_0777.

    Phylogenomic databases

    eggNOGi COG0462.
    HOGENOMi HOG000210449.
    KOi K00948.
    OMAi EVANKNC.
    OrthoDBi EOG6Z99XQ.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00172 .
    BioCyci MMAR394221:GHNB-769-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 2 hits.
    HAMAPi MF_00583_B. RibP_PPkinase_B.
    InterProi IPR000842. PRib_PP_synth_CS.
    IPR029099. Pribosyltran_N.
    IPR029057. PRTase-like.
    IPR005946. Rib-P_diPkinase.
    [Graphical view ]
    Pfami PF14572. Pribosyl_synth. 1 hit.
    PF13793. Pribosyltran_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
    PROSITEi PS00114. PRPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MCS10.

    Entry informationi

    Entry nameiKPRS_MARMM
    AccessioniPrimary (citable) accession number: Q0ARN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3