Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0ARN5 (KPRS_MARMM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase

Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Ordered Locus Names:Mmar10_0759
OrganismMaricaulis maris (strain MCS10) [Complete proteome] [HAMAP]
Taxonomic identifier394221 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_1000025453

Regions

Region209 – 22214Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1251Magnesium Potential
Metal binding1271Magnesium Potential
Metal binding1361Magnesium Potential
Metal binding1401Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q0ARN5 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: EDD7EBA82C22DC19

FASTA31033,732
        10         20         30         40         50         60 
MKLMSGTANP DLSRSIADYL DAPLTASHIE RFADGEIFVR IDENVRGEDV FILQSTSRPA 

        70         80         90        100        110        120 
NDHLMELLIC IDALVRASAR RITAVIPYFG YARQDRKTGG RTPISAKLVA NLIAKAGADR 

       130        140        150        160        170        180 
VLTVDLHAGQ IQGFFDIPTD NLFATKVMEA DIRRHYETDN LLIVSPDVGG VVRARALAKL 

       190        200        210        220        230        240 
LDAEIAIVDK RRPKAGVAEV MNIIGEVEGR RCILFDDMCD SGGTLVNAAD ALLEKGAIEV 

       250        260        270        280        290        300 
SAYVTHGVLS KDAQGRVDKS RLRELVVTDS VTEPPNSTAT PKVRRLSVAP LLGEAIRRIA 

       310 
NDESVSKLFD 

« Hide

References

[1]"Complete sequence of Maricaulis maris MCS10."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000449 Genomic DNA. Translation: ABI65052.1.
RefSeqYP_755990.1. NC_008347.1.

3D structure databases

ProteinModelPortalQ0ARN5.
SMRQ0ARN5. Positions 1-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394221.Mmar10_0759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI65052; ABI65052; Mmar10_0759.
GeneID4286502.
KEGGmmr:Mmar10_0759.
PATRIC22449540. VBIMarMar77530_0777.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAEVANKNC.
OrthoDBEOG6Z99XQ.

Enzyme and pathway databases

BioCycMMAR394221:GHNB-769-MONOMER.
UniPathwayUPA00087; UER00172.

Family and domain databases

Gene3D3.40.50.2020. 2 hits.
HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_MARMM
AccessionPrimary (citable) accession number: Q0ARN5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways