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Q0ARN5

- KPRS_MARMM

UniProt

Q0ARN5 - KPRS_MARMM

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Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi125 – 1251MagnesiumUniRule annotation
Metal bindingi127 – 1271MagnesiumUniRule annotation
Metal bindingi136 – 1361MagnesiumUniRule annotation
Metal bindingi140 – 1401MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. ribose phosphate diphosphokinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. nucleotide biosynthetic process Source: UniProtKB-KW
  3. ribonucleoside monophosphate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-769-MONOMER.
UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Short name:
P-Rib-PP synthaseUniRule annotation
Short name:
PRPP synthaseUniRule annotation
Gene namesi
Name:prsUniRule annotation
Ordered Locus Names:Mmar10_0759
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Ribose-phosphate pyrophosphokinasePRO_1000025453Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_0759.

Structurei

3D structure databases

ProteinModelPortaliQ0ARN5.
SMRiQ0ARN5. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 22214Binding of phosphoribosylpyrophosphateSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiEVANKNC.
OrthoDBiEOG6Z99XQ.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ARN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLMSGTANP DLSRSIADYL DAPLTASHIE RFADGEIFVR IDENVRGEDV
60 70 80 90 100
FILQSTSRPA NDHLMELLIC IDALVRASAR RITAVIPYFG YARQDRKTGG
110 120 130 140 150
RTPISAKLVA NLIAKAGADR VLTVDLHAGQ IQGFFDIPTD NLFATKVMEA
160 170 180 190 200
DIRRHYETDN LLIVSPDVGG VVRARALAKL LDAEIAIVDK RRPKAGVAEV
210 220 230 240 250
MNIIGEVEGR RCILFDDMCD SGGTLVNAAD ALLEKGAIEV SAYVTHGVLS
260 270 280 290 300
KDAQGRVDKS RLRELVVTDS VTEPPNSTAT PKVRRLSVAP LLGEAIRRIA
310
NDESVSKLFD
Length:310
Mass (Da):33,732
Last modified:October 17, 2006 - v1
Checksum:iEDD7EBA82C22DC19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65052.1.
RefSeqiYP_755990.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI65052; ABI65052; Mmar10_0759.
GeneIDi4286502.
KEGGimmr:Mmar10_0759.
PATRICi22449540. VBIMarMar77530_0777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65052.1 .
RefSeqi YP_755990.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0ARN5.
SMRi Q0ARN5. Positions 1-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_0759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI65052 ; ABI65052 ; Mmar10_0759 .
GeneIDi 4286502.
KEGGi mmr:Mmar10_0759.
PATRICi 22449540. VBIMarMar77530_0777.

Phylogenomic databases

eggNOGi COG0462.
HOGENOMi HOG000210449.
KOi K00948.
OMAi EVANKNC.
OrthoDBi EOG6Z99XQ.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00172 .
BioCyci MMAR394221:GHNB-769-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 2 hits.
HAMAPi MF_00583_B. RibP_PPkinase_B.
InterProi IPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view ]
Pfami PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
PROSITEi PS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiKPRS_MARMM
AccessioniPrimary (citable) accession number: Q0ARN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3