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Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose-5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP.UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathway:i5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase (prs)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Ribose-5-phosphateUniRule annotation
Metal bindingi125 – 1251MagnesiumUniRule annotation
Metal bindingi127 – 1271MagnesiumUniRule annotation
Binding sitei127 – 1271ATPUniRule annotation
Binding sitei132 – 1321ATPUniRule annotation
Metal bindingi136 – 1361MagnesiumUniRule annotation
Metal bindingi140 – 1401MagnesiumUniRule annotation
Binding sitei167 – 1671Ribose-5-phosphateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 363ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-769-MONOMER.
UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
5-phospho-D-ribosyl alpha-1-diphosphateUniRule annotation
Phosphoribosyl diphosphate synthaseUniRule annotation
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Short name:
P-Rib-PP synthaseUniRule annotation
Short name:
PRPP synthaseUniRule annotation
Short name:
PRPPaseUniRule annotation
Gene namesi
Name:prsUniRule annotation
Ordered Locus Names:Mmar10_0759
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Ribose-phosphate pyrophosphokinasePRO_1000025453Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_0759.

Structurei

3D structure databases

ProteinModelPortaliQ0ARN5.
SMRiQ0ARN5. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1923Ribose-5-phosphate bindingUniRule annotation
Regioni217 – 2248Ribose-5-phosphate bindingUniRule annotation
Regioni304 – 3063Ribose-5-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiGEAINRT.
OrthoDBiEOG6Z99XQ.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ARN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMSGTANP DLSRSIADYL DAPLTASHIE RFADGEIFVR IDENVRGEDV
60 70 80 90 100
FILQSTSRPA NDHLMELLIC IDALVRASAR RITAVIPYFG YARQDRKTGG
110 120 130 140 150
RTPISAKLVA NLIAKAGADR VLTVDLHAGQ IQGFFDIPTD NLFATKVMEA
160 170 180 190 200
DIRRHYETDN LLIVSPDVGG VVRARALAKL LDAEIAIVDK RRPKAGVAEV
210 220 230 240 250
MNIIGEVEGR RCILFDDMCD SGGTLVNAAD ALLEKGAIEV SAYVTHGVLS
260 270 280 290 300
KDAQGRVDKS RLRELVVTDS VTEPPNSTAT PKVRRLSVAP LLGEAIRRIA
310
NDESVSKLFD
Length:310
Mass (Da):33,732
Last modified:October 17, 2006 - v1
Checksum:iEDD7EBA82C22DC19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI65052.1.
RefSeqiWP_011642699.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI65052; ABI65052; Mmar10_0759.
KEGGimmr:Mmar10_0759.
PATRICi22449540. VBIMarMar77530_0777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI65052.1.
RefSeqiWP_011642699.1. NC_008347.1.

3D structure databases

ProteinModelPortaliQ0ARN5.
SMRiQ0ARN5. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi394221.Mmar10_0759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI65052; ABI65052; Mmar10_0759.
KEGGimmr:Mmar10_0759.
PATRICi22449540. VBIMarMar77530_0777.

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiGEAINRT.
OrthoDBiEOG6Z99XQ.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172.
BioCyciMMAR394221:GHNB-769-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiKPRS_MARMM
AccessioniPrimary (citable) accession number: Q0ARN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: July 22, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.