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Q0AQC2

- PDXA_MARMM

UniProt

Q0AQC2 - PDXA_MARMM

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Metal bindingi177 – 1771Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi222 – 2221Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi277 – 2771Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei285 – 2851SubstrateUniRule annotation
    Binding sitei294 – 2941SubstrateUniRule annotation
    Binding sitei303 – 3031SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciMMAR394221:GHNB-1246-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:Mmar10_1222
    OrganismiMaricaulis maris (strain MCS10)
    Taxonomic identifieri394221 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
    ProteomesiUP000001964: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3403404-hydroxythreonine-4-phosphate dehydrogenasePRO_1000081867Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi394221.Mmar10_1222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AQC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiAIGTEDE.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0AQC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQLSPVAVS MGDPAGIGPE IILKAWQSWR RRNGVPPLIA LGDIDAFTAT    50
    AQALGLPAPC PLPTPTREAA ETLDGLPVFD VGVKIAAPVR PGQPDTANAA 100
    CTKAAIETGV RLALDGQVSA LVTAPIAKSV MYEAGFAFPG HTEFLAELCA 150
    DHPVDGPKGP AMMLAGGGLR VVLVTIHEPL VRALSLITPQ RVEATARITD 200
    AALRRDFGIA RPRLALAGLN PHAGEGGALG DEEIDILDPL AARLRADGID 250
    ITDAQPPDTL FHAEARAGYD AAICLYHDQG LIPVKTLDFH GGVNITLGLP 300
    IVRTSPDHGT AFNIAGQGVA RPDSLLAALE QAVKIAECRA 340
    Length:340
    Mass (Da):35,313
    Last modified:October 17, 2006 - v1
    Checksum:iA848338DB11C6121
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65515.1.
    RefSeqiYP_756453.1. NC_008347.1.

    Genome annotation databases

    EnsemblBacteriaiABI65515; ABI65515; Mmar10_1222.
    GeneIDi4286475.
    KEGGimmr:Mmar10_1222.
    PATRICi22450514. VBIMarMar77530_1250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65515.1 .
    RefSeqi YP_756453.1. NC_008347.1.

    3D structure databases

    ProteinModelPortali Q0AQC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394221.Mmar10_1222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI65515 ; ABI65515 ; Mmar10_1222 .
    GeneIDi 4286475.
    KEGGi mmr:Mmar10_1222.
    PATRICi 22450514. VBIMarMar77530_1250.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi AIGTEDE.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci MMAR394221:GHNB-1246-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MCS10.

    Entry informationi

    Entry nameiPDXA_MARMM
    AccessioniPrimary (citable) accession number: Q0AQC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3