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Q0AQC2

- PDXA_MARMM

UniProt

Q0AQC2 - PDXA_MARMM

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, Mmar10_1222
Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411Substrate By similarity
Binding sitei142 – 1421Substrate By similarity
Metal bindingi177 – 1771Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi222 – 2221Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi277 – 2771Divalent metal cation; shared with dimeric partner By similarity
Binding sitei285 – 2851Substrate By similarity
Binding sitei294 – 2941Substrate By similarity
Binding sitei303 – 3031Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-1246-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:Mmar10_1222
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3403404-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000081867Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi394221.Mmar10_1222.

Structurei

3D structure databases

ProteinModelPortaliQ0AQC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiAIGTEDE.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AQC2-1 [UniParc]FASTAAdd to Basket

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MTQLSPVAVS MGDPAGIGPE IILKAWQSWR RRNGVPPLIA LGDIDAFTAT    50
AQALGLPAPC PLPTPTREAA ETLDGLPVFD VGVKIAAPVR PGQPDTANAA 100
CTKAAIETGV RLALDGQVSA LVTAPIAKSV MYEAGFAFPG HTEFLAELCA 150
DHPVDGPKGP AMMLAGGGLR VVLVTIHEPL VRALSLITPQ RVEATARITD 200
AALRRDFGIA RPRLALAGLN PHAGEGGALG DEEIDILDPL AARLRADGID 250
ITDAQPPDTL FHAEARAGYD AAICLYHDQG LIPVKTLDFH GGVNITLGLP 300
IVRTSPDHGT AFNIAGQGVA RPDSLLAALE QAVKIAECRA 340
Length:340
Mass (Da):35,313
Last modified:October 17, 2006 - v1
Checksum:iA848338DB11C6121
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65515.1.
RefSeqiYP_756453.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI65515; ABI65515; Mmar10_1222.
GeneIDi4286475.
KEGGimmr:Mmar10_1222.
PATRICi22450514. VBIMarMar77530_1250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65515.1 .
RefSeqi YP_756453.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0AQC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_1222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI65515 ; ABI65515 ; Mmar10_1222 .
GeneIDi 4286475.
KEGGi mmr:Mmar10_1222.
PATRICi 22450514. VBIMarMar77530_1250.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi AIGTEDE.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci MMAR394221:GHNB-1246-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiPDXA_MARMM
AccessioniPrimary (citable) accession number: Q0AQC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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